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Glycomicrobiology (Paperback, Softcover reprint of the original 1st ed. 2002)
Loot Price: R2,936
Discovery Miles 29 360
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Glycomicrobiology (Paperback, Softcover reprint of the original 1st ed. 2002)
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At one time, it was thought that only eukaryotic cells could
glycosylate proteins. Two major kinds of glycoproteins were
recognized in animal cells, consisting of O- or N-linked
saccharides. The O-linked saccharides were derived from gly-
sylation of threonine or serine, whereas N-linked saccharides were
derived from asparagine. In recent years, numerous glycoproteins
have been found in bacteria, many of which do not possess typical
animal cell glycosylation patterns. One of the purposes of this
volume is to provide a thorough discussion of c- bohydrate-peptide
linkages in bacteria. Interestingly, though Braun's lipoprotein of
some gram-negative bacteria was discovered nearly three decades
ago, it was never considered to be a glycoprotein, even though it
possessed a peptide-car- hydrate linkage. In the past few years, it
is clear that even gram-positive cells can covalently bind proteins
to their cell walls. The role of carbohydrates in the rec- nition
of animal cells by bacteria is now well established.
Saccharide-specific - hesins have been sequenced, cloned and
employed as potential vaccines. Furth- more, carbohydrate receptors
on animal cells for bacterial adhesins have been identified and
characterized. Another purpose for this volume is to provide a
forum for new information on adhesin-receptor complexes involving
bacterial pathogens. There now is a b- geoning literature on
carbohydrate structure, function, and molecular biology in
bacteria. The role of carbohydrates in biotechnology and biomass
utilization has become important in the past decade due to new
methods for carbohydrate det- tion and the cloning of biosynthetic
and degradative enzymes.
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