Reduced production of DHEA associated with the diseases that
accompany aging has led to its use as a nutritional supplement for
antiaging, metabolic support, and other purposes. While animal
studies have clearly shown substantial benefits of DHEA in
combating various disease states, the effect of low levels of DHEA
in humans is less established, and the mechanisms of action and
potential involvement in illnesses remain unclear. DHEA in Human
Health and Aging reviews the past ten years of research into this
hormone and explores its potential for future study.
With contributions from a cadre of international experts, this
volume examines:
- The biology of DHEA relevant to health in humans
- Areas of potential clinical importance concerning low levels of
DHEA related to age or physiological change
- Prevention as well as treatment of various human disease states
by changing DHEA levels
- The use of DHEA levels in predicting the risk of disease
- The role of DHEA in diabetes, fitness, infectious disease,
cancer, AIDS, bone health, cardiovascular diseases, autism, and
mental health
- Animal models and their relation to studies done on humans
- The effects of loss of adrenal gland function, the subsequent
reduction in DHEA production, and its replacement as therapy
- Adverse effects in DHEA-supplemented women
- Mechanisms of action of DHEA in prostate and ovarian health,
vascular modification, stress, memory, aggression, and Alzheimer's
disease
Covering a wide range of topics, the book is compiled from
contributions of experts who have each studied some aspect of DHEA
and human or animal health or disease. Every chapter is
self-contained, allowing for focused study on individual topics.
Edited by one of the leading experts in the field of nutrition, the
book presents a compelling view of the state of the science in
DHEA.
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