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Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
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Integration of Pharmaceutical Discovery and Development - Case Histories (Hardcover, 1998 ed.)
Loot Price: R5,838
Discovery Miles 58 380
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Integration of Pharmaceutical Discovery and Development - Case Histories (Hardcover, 1998 ed.)
Series: Pharmaceutical Biotechnology, 11
Expected to ship within 10 - 15 working days
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In the late 1980s, it became painfully evident to the
pharmaceutical industry that the old paradigm of drug discovery,
which involved highly segmented drug - sign and development
activities, would not produce an acceptable success rate in the
future. Therefore, in the early 1990s a paradigm shift occurred in
which drug design and development activities became more highly
integrated. This new str- egy required medicinal chemists to design
drug candidates with structural f- tures that optimized
pharmacological (e. g. , high affinity and specificity for the
target receptor), pharmaceutical (e. g. , solubility and chemical
stability), bioph- maceutical (e. g. , cell membrane permeability),
and metabolic/pharmacokinetic (e. g. , metabolic stability,
clearance, and protein binding) properties. Successful
implementation of this strategy requires a multidisciplinary team
effort, incl- ing scientists from drug design (e. g. , medicinal
chemists, cell biologists, en- mologists, pharmacologists) and drug
development (e. g. , analytical chemists, pharmaceutical
scientists, physiologists, and molecular biologists representing
the disciplines of pharmaceutics, biopharmaceutics, and
pharmacokinetics/drug metabolism). With this new, highly integrated
approach to drug design now widely utilized by the pharmaceutical
industry, the editors of this book have provided the sci- tific
community with case histories to illustrate the nature of the
interdisciplinary interactions necessary to successfully implement
this new approach to drug d- covery. In the first chapter, Ralph
Hirschmann provides a historical perspective of why this paradigm
shift in drug discovery has occurred.
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