Integration of Pharmaceutical Discovery and Development - Case Histories (Hardcover, 1998 ed.)

In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and metabolic/pharmacokinetic (e. g. , metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g. , medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g. , analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.

General

Imprint:	Kluwer Academic / Plenum Publishers
Country of origin:	United States
Series:	Pharmaceutical Biotechnology, 11
Release date:	August 1998
First published:	1998
Editors:	Ronald T. Borchardt • Roger M. Freidinger • Tomi K. Sawyer • Philip L. Smith
Dimensions:	229 x 152 x 39mm (L x W x T)
Format:	Hardcover
Pages:	610
Edition:	1998 ed.
ISBN-13:	978-0-306-45743-2
Categories:	Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > Animal physiology Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
LSN:	0-306-45743-1
Barcode:	9780306457432

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