The Human Brain Circulation offers an original, up-to-date
synthesis and summary of our current knowledge of the
cerebrovascular circulatory system, with special emphasis on the
study of isolated vessels. The contributors describe the normal
vasculature and the many complex changes that occur with age and
disease. Fetal and newborn circulation is also addressed. In areas
where knowledge of human vessels is deficient, research on animal
tissues is included.
The book is significant because it challenges some of the
traditional assumptions based on animal studies of the mechanisms
that control human brain vasculature and presents a contemporary
view that includes the role of shear stress and intravascular
pressure on the arterial circulation.
Among the topics discussed are the receptors for vasoactive
substances; the molecular aspects of endothelial function in
hemostasis; inflammation and thrombosis; the effect of
hypertension; the pathophysiology of vasospasm, ischemia, and
reperfusion; and the actions of free radicals. Techniques for the
in vivo study of cerebrovascular dysfunction are also described.
The Human Brain Circulation presents a definitive understanding of
this centrally important vascular bed and clearly defines the
future direction for research into human cerebrovascular disease
and its treatment.
General
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