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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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Chromosome Structure and Function - Impact of New Concepts (Paperback, Softcover reprint of the original 1st ed. 1988)
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Chromosome Structure and Function - Impact of New Concepts (Paperback, Softcover reprint of the original 1st ed. 1988)
Series: Stadler Genetics Symposia Series
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A Historical Perspective on the Study of Chromosome Structure and
Function R. Appels Division of Plant Industry CSIRO P.O. Box 1600
A.C.T. AUSTRALIA "Modern physical science gives us no model to
explain the re duplication of the gene-string in each cell
generation, or to ex plain the production of effective quantities
of specific enzymes or other agents by specific genes. The precise
pairing and inter change of segments by homologous gene-strings at
meiosis also suggest novel physical properties of this form of
matter." Stadler (1954) The very strong influence of reductionism
in the history of understanding chromosome structure and function
is evident in the above quotation from Stadler's 1954 paper, "The
gene." Earlyob servations on the constancy of the cytological
appearance of chromo somes and their regular behaviour in cell
division led to specula tion on their biological importance. As
genetics became more refined in the early decades of the 20th
century the genes-on-a string model of chromosomes developed and
greater emphasis was placed on the further dissection of these
structures. As a result, in the 1980's the reductionist approach is
reaching a crest as extensive regions of the genetic material are
being sequenced."
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