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Histological Typing of Soft Tissue Tumours (Paperback, 2nd ed. 1994)
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Histological Typing of Soft Tissue Tumours (Paperback, 2nd ed. 1994)
Series: WHO. World Health Organization. International Histological Classification of Tumours
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The first edition of Histological Typing of Soft Tissue Tumours,
pub- lished in 1969, represented a major step in the
standardization of nomen- clature in this specialty area.
Accompanied by a glass slide set of more than a hundred common and
exotic tumours, this book resulted in the rapid assimilation of a
universal set of guidelines and diagnostic defini- tions by
pathologists in many countries. In the intervening two decades
numerous changes have occurred, and our committee has been chal-
lenged by the desire to incorporate new and exciting findings from
the areas of immunohistochemistry and molecular biology into the
classifi- cation with the need to develop a simple reproducible
classification for practising pathologists. The current system,
while based principally on standard microscopic observations,
acknowledges and cites the use of di- agnostically valuable
ancillary techniques. Changes in the Classification Although the
original classification utilized the concept of "histogene- sis" or
tissue of origin in defining tumours, we have departed from that
point of view, acknowledging the impossibility of determining
histogen- esis by morphologic means alone. This classification is
based on the "line of differentiation", or stated simply, by
comparing tumours to the nor- mal cell they most closely resemble
without necessarily implying origin therefrom. As in the old
classification we have interpreted the term "tu- mours" in the
broadest sense of the word and have, therefore, included neoplastic
and non-neoplastic conditions.
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