Bladder cancer is the fifth most common form of cancer worldwide
and is mainly prevalent in developed countries. It is thought to
arise through two distinct pathways: the noninvasive and the
invasive. The noninvasive pathway gives rise to a superficial
papillary carcinoma that is characterized by activating mutations
in oncogenes such as H-ras, FGFR3 and PI3K. This pathway is rarely
lethal as superficial papillary carcinomas can be readily removed
through transurethral resection. However, 15% of noninvasive
urothelial tumors can transform into invasive carcinomas and have
high recurrence (80% of the cases) that requires intensive
surveillance and repetitive treatment. This book discusses the risk
factors of bladder cancer, as well as the emerging treatment
strategies and challenges.
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