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JAK-STAT Signalling - Methods and Protocols (Hardcover, 2013 ed.)
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JAK-STAT Signalling - Methods and Protocols (Hardcover, 2013 ed.)
Series: Methods in Molecular Biology, 967
Expected to ship within 12 - 17 working days
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The receptor-associated JAK protein kinases and their substrates,
the STAT transcriptional activators, transmit signals following
cytokine and growth factor binding to receptors expressed on the
cell surface, to result in specific transcriptional and cellular
responses. Over the last two decades, the field has progressed from
identification of the individual components through to an
understanding of the activation and deactivation mechanisms, and
the complex structural detail of the proteins involved. We now know
that these pathways are important in many biological processes,
including growth and development, hematopoiesis, and the innate and
adaptive immune response. JAK-STAT Signalling: Methods and
Protocols provides detailed methodologies for examining many
aspects of the pathway. Divided into four sections, topics include
JAK and STAT specific approaches, the negative regulators of the
pathway (SOCS proteins), and the production and crystallization of
JAK and STAT proteins, among others. Written in the successful
Methods in Molecular Biology (TM) series format, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
protocols, and notes on troubleshooting and avoiding known
pitfalls. Authoritative and easily accessible, JAK-STAT Signalling:
Methods and Protocols will be of use not only to those working in
the area but also to new investigators who are led to delve into
the complexities of JAK and STAT responses.
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