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Heam Polymerization and Its Inhibition by Antimalarial Drug (Paperback)
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Heam Polymerization and Its Inhibition by Antimalarial Drug (Paperback)
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Malaria is one of the most common diseases in developing countries
and poses a great challenge to world health. Resistance of malaria
parasites to available antimalarial drugs remains the main
challenge to the effective control of the disease. The
physiological conditions prevailing with in the acidic digestive
vacuoles of the malaria parasites provide a suitable physiochemical
environment for conversion of heam to beta-hematin/hemozoin. Though
the both protein as well as lipids mediated beta-hematin formation
remain valid hypothesis but later seems to be more relevant, when
mechanism of hemozoin synthesis is considered as a simple
physiochemical reaction. Some repeats earlier heme show loss of
beta-hematin formation activity of the parasite lysate by protenase
K and heat treatment. The digestion of this cytosol, which consists
essentially of hemoglobin results in the formation of potentially
toxic ferriprotoporphyrin IX (FP). Several antimalarial drugs are
thought to exert their effect by complexing with FP, thus
inhibiting its detoxification through polymerization to hemozoin.
Our aim shows that inhibition of heam polymerization by Arteether.
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