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Bacterial Artificial Chromosomes - Volume 2: Functional Studies (Paperback, Softcover reprint of hardcover 1st ed. 2004)
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Bacterial Artificial Chromosomes - Volume 2: Functional Studies (Paperback, Softcover reprint of hardcover 1st ed. 2004)
Series: Methods in Molecular Biology, 256
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Several developmental and historical threads are woven and
displayed in these two volumes of Bacterial Artificial Chromosomes,
the first on Library Construction, Physical Mapping, and
Sequencing, and the second on Fu- tional Studies. The use of
large-insert clone libraries is the unifying feature, with many
diverse contributions. The editors have had quite distinct roles.
Shaying Zhao has managed several BAC end-sequencing projects.
Marvin Stodolsky during 1970-1980 contributed to the elucidation of
the natural b- teriophage/prophage P1 vector system. Later, he
became a member of the Genome Task Group of the Department of
Energy (DOE), through which s- port flowed for most clone library
resources of the Human Genome Program (HGP). Some important
historical contributions are not represented in this volume. This
preface in part serves to mention these contributions and also
briefly surveys historical developments. Leon Rosner (deceased)
contributed substantially in developing a PAC library for
drosophila that utilized a PI virion-based encapsidation and tra-
fection process. This library served prominently in the Drosophila
Genome Project collaboration. PACs proved easy to purify so that
they substantially replaced the YACs used earlier. Much of the
early automation for massive clone picking and processing was
developed at the collaborating Lawrence Berkeley National
Laboratory. However, the P1 virion encapsidation system itself was
too fastidious, and P1 virion-based methods did not gain popularity
in other genome projects.
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