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Mycoplasma Cell Membranes (Paperback, Softcover reprint of the original 1st ed. 1993)
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Mycoplasma Cell Membranes (Paperback, Softcover reprint of the original 1st ed. 1993)
Series: Subcellular Biochemistry, 20
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The mycoplasmas, a trivial name used to denote organisms included
in the class Mollicutes, are a group of prokaryotic organisms
comprising more than 120 species distinguished from ordinary
bacteria by their small size and the total lack of cell walls. The
absence of a cell wall in mycoplasmas is a characteristic of
outstanding importance to which the mycoplasmas owe many of their
pecu liarities, for example, their morphological instability,
osmotic sensitivity, unique ion pumping systems, resistance to
antibiotics that interfere with cell wall bio synthesis, and
susceptibility to lysis by detergents and alcohols. The fact that
the mycoplasma cells contain only one membrane type, the plasma
membrane, constitutes one of their most useful properties for
membrane studies; once the membrane is isolated, it is
uncontaminated with other mem brane types. Another advantage in
using mycoplasmas as models for membrane studies stems from the
fact that their membrane lipid composition can be altered in a
controlled manner. This characteristic results from the partial or
total inabili ty of the mycoplasmas to synthesize long-chain fatty
acids and cholesterol, making mycoplasmas dependent on the supply
of fatty acids from the growth medium. The ability to introduce
controlled alterations in the fatty acid composi tion and
cholesterol content of mycoplasma membranes has been utilized in
studying the molecular organization and physical properties of
biological mem branes.
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