All aspects of sleep sciences are included in this excellent
resource text, with special reference to sleep substances and sleep
modulators. The historical development of the theories of sleep are
reviewed in conjunction with the technical problems. All candidate
substances are overviewed as to their sites of presence, chemical
nature, bioassay techniques, physiological and pharmacological
effects. On the basis of a standardized methodology developed by
the author, sleep-modulatory characteristics of some substances are
compared and evaluated in quantitative terms. The sleep regulatory
mechanisms, which are composed of complex neurohumoral subsystems,
are analyzed from the results of recent neurophysiological and
neuroendocrinological experiments. Furthermore, an evolutionary
aspect of sleep substances is taken into consideration. Chapters
Highlight: Techniques for isolation and evaluation Prostaglandins
Paradoxical sleep factors Sleep-promoting substances and
nucleosides
General
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