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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Cytochrome P450 2D6 - Structure, Function, Regulation and Polymorphism (Hardcover)
Loot Price: R7,659
Discovery Miles 76 590
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Cytochrome P450 2D6 - Structure, Function, Regulation and Polymorphism (Hardcover)
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Cytochromes are proteins that catalyze electron transfer reactions
of well-known metabolic pathways and are classified in various
superfamilies. The CYP, or P450, superfamily accounts for 90% of
the oxidative metabolism of clinical drugs. One member of this
superfamily, P450 2D6 (or CYP2D6), singlehandedly metabolizes about
25% of all medications in the human liver. Cytochrome P450 2D6:
Structure, Function, Regulation, and Polymorphism reviews the
current knowledge of CYP2D6 as well as the maturing body of
evidence indicating its significance to clinical and
pharmacological researchers and practitioners. This book focuses on
the critical role CYP2D6 plays in the human liver. It examines the
genetic, epigenetic, physiological, pathological, and structural
factors of the gene that govern the highly variable metabolism of a
number of drugs in clinical use. It highlights the impact of the
functional roles of CYP2D6 on clinical practice and drug
development and also discusses implications for precise medicine,
strategies to avoid adverse drug reactions, and paths for future
research. Cytochrome P450 2D6 is a unique, valuable book focusing
on a single but immensely powerful human gene. It provides the
first single source of comprehensive information on CYP2D6 that
serves as an important reference for medical, biomedical,
pharmaceutical, and nursing researchers, practitioners, and
students.
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