Host Response to Biomaterials explains the various categories of
biomaterials and their significance for clinical applications, with
a focus on the host response to each biomaterial. It also explores
the role of the immune system in host response, and covers the
regulatory environment for biomaterials. The benefits of synthetic
versus natural biomaterials are discussed, as is the transition
from simple to complex biomaterial solutions.
Dr. Badylak and a team of expert contributors have pooled their
experience in this volume, in order to contribute to the effort to
make interactive biomaterials with the ability to respond to the
tissue microenvironment and direct the host response. The range of
fields covered is extensive; including, but not limited to,
orthopaedic, surgery, dental, general surgery, neurosurgery, lower
urinary tract, and regenerative medicine. This is one of the first
books to connect immunology and biomaterials in regard to host
response.
Author response to reviews;
I agree with the comments that were made especially regarding
the intended emphasis upon the host response being the motivating
concept behind the book. We really do not need another biomaterials
textbook, but we do need something that interrogates and explains
the host response. Much of the comments revolved around the titles
of the sections/chapters and indeed that is easy enough to remedy.
I am not interested in editing another book on various types of
biomaterials, but obviously the various types of biomaterials will
elicit a different and probably unique type of host response. This
information will be important to not only practicing physicians,
but also medical device companies designing next generation
biomaterials, as well as students and research scientists
interested in developing such materials for clinical use and
regenerative medicine purposes. The key is the host response. The
list of contributors will be scientists interested in the innate
immune response, host-biomaterial interfaces, etc ..not classic
material scientists. There are no textbooks to my knowledge with
this focus in mind. One either has to go to the traditional
immunology literature which is heavily slanted toward mechanisms of
T-cell, B-cell, and dendritic cell biology, or to classic
biomaterials literature and try to connect the two. The purpose of
this textbook is to fill that void.
I do plan to change the TOC. The new table will reflect the host
response emphasis of the chapters. FYI, when I prepared the draft
of the TOC, I was thinking in terms of general categories of
materials to which the host must respond (and the chapters that
would address this). My error was in listing this with respect more
to the different biomaterials rather than the host response. I will
need to think of how to emphasize my intent in the chapter titles
without sounding too repetitive.
There will definitely be a chapter, probably several, on
combination/hybrid devices/materials. These will include the
bioactive devices ie., devices functionalized with various
bioactive factors. I will add this to the TOC.
I do not plan to place great emphasis on the regulatory issues
regarding the materials and the host response but I will like
suggest one chapter on the view of the regulatory agencies with
respect to the various types of device categories
The host response to different classes of biomaterials
The impact of host response on the success or failure of a
biomaterial
About regulations regarding combination devices"
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