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Chasing Men on Fire - The Story of the Search for a Pain Gene (Hardcover)
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Chasing Men on Fire - The Story of the Search for a Pain Gene (Hardcover)
Series: Chasing Men on Fire
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A thirty-year quest, from genes to pain-signaling neurons to people
with a rare genetic disorder that makes them feel they are on fire.
Two soldiers, both with wounds injuring the same nerve, show very
different responses: one is disabled by neuropathic pain, unable to
touch the injured limb because even the lightest contact triggers
excruciating discomfort; the other notices numbness but no pain at
all. Could the difference lie in their genes? In this book,
described in the foreword by Nobel Laureate James Rothman as "so
well written that it reads like a detective novel," Stephen Waxman
recounts the search for a gene that controls pain-a search spanning
more than thirty years and three continents. The story moves from
genes to pain-signaling neurons that scream when they should be
silent to people with a rare genetic disorder who feel they are on
fire. Waxman explains that if pain-signaling neurons are injured by
trauma or disease, they can become hyperactive and send pain
signals to the brain even without external stimulus. Studying the
hyperactive mutant pain gene in man on fire syndrome has pointed
the way to molecules that produce pain more broadly within the
general population, in the rest of us. Waxman's account of the many
steps that led to discovery of the pain gene tells the story behind
the science, of how science happens.
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