The secretions of the exocrine pancreas provide for digestion of a
meal into components that are then available for processing and
absorption by the intestinal epithelium. Without the exocrine
pancreas, malabsorption and malnutrition result. This chapter
describes the cellular participants responsible for the secretion
of digestive enzymes and fluid that in combination provide a
pancreatic secretion that accomplishes the digestive functions of
the gland. Key cellular participants, the acinar cell and the duct
cell, are responsible for digestive enzyme and fluid secretion,
respectively, of the exocrine pancreas. This chapter describes the
neurohumoral pathways that mediate the pancreatic response to a
meal as well as details of the cellular mechanisms that are
necessary for the organ responses, including protein synthesis and
transport and ion transports, and the regulation of these responses
by intracellular signaling systems. Examples of pancreatic diseases
resulting from dysfunction in cellular mechanisms provide emphasis
of the importance of the normal physiologic mechanisms. Table of
Contents: Introduction / Anatomy / Pancreatic Embryology and
Development / Digestive Enzymes / Water and Ion Secretion from the
Pancreatic Ductal System / Regulation of Whole-Organ Pancreatic
Secretion / Measurement of Exocrine Pancreatic Secretion in Humans
/ Clinical Application of Knowledge of Pancreatic Physiology /
Summary / References
General
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