Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Cancer Markers - Diagnostic and Developmental Significance (Hardcover, 1980 ed.)
Loot Price: R5,761
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Cancer Markers - Diagnostic and Developmental Significance (Hardcover, 1980 ed.)
Series: Contemporary Biomedicine, 1
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Developmental cancer products (oncodevelopmental markers, ODM) not
only serve as diagnostic and prognostic indicators but also may be
used to study the nature of the carcinogenic process and the
biology of tumors. For many years oncologists have searched for
markers of cancer cells that would permit unequivocal recognition
of cancer in contrast to noncancerous tissue. The earliest and
still most widely used method of identification of cancer tissue or
cells is the structural resemblance of cancer tissue to fetal or
immature tissue. Pathologists not only recognize cancer by its
morphologic similarity to fetal tissues, but also in many instances
can relate the behavior of a given tumor to the degree of tissue
differentiation. Thus, poorly differentiated tumors that resemble
fetal tissue generally grow more rapidly and metastasize earlier
than do well-differentiated tumors that more closely resemble adult
tissue. In recent years the commonality of fetal and cancer tissue
has been extended to products of tumor cells that, can be analyzed
by biochemical, immunological, or physiological techniques. Increas
ingly, products of cancer cells similar to fetal products are being
identified and studied. These products range from cell-surface
markers (fetal or differentiation antigens), placental proteins,
hormones, and isoenzymes to a multitude of products, such as
carcinoembryonic antigen (CEA), alphafetoprotein (AFP), lymphocyte
markers, and nucleic acids, such as tRNA, that are produced in
small amounts by v vi PREFACE continually differentiating cells in
the adult but in much greater amounts by tumors."
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