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Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids (Hardcover)
Loot Price: R4,534
Discovery Miles 45 340
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Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids (Hardcover)
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Advances in Nanomedicine for the Delivery of Therapeutic Nucleic
Acids addresses several issues related to safe and effective
delivery of nucleic acids (NAs) using nanoparticles. A further
emphasis would be laid on the mechanism of delivery of NAs, the
barriers encountered and the strategies adapted to combat them. An
exhaustive account of the advantages as well shortcomings of all
the delivery vectors being employed in delivery of various NAs will
be provided. On final note the regulatory aspects of nanoparticles
mediated NA would be discussed, with focus on their clinical
relevance. The design and development of nucleic acid-based
therapeutics for the treatment of diseases arising from genetic
abnormalities has made significant progress over the past few
years. NAs have been widely explored for the treatment of cancer
and infectious diseases or to block cell proliferation and thereby
caused diseases. Advances in synthetic oligonucleotide chemistry
resulted in synthesis of NAs that are relatively stable in in vivo
environments. However, cellular targeting and intracellular
delivery of NAs still remains a challenge. Further development of
NA-based therapeutics depends on the progress of safe and effective
carriers for systemic administration. Nanomedicine has facilitated
availability of vectors with diminished cytotoxicity and enhanced
efficacy which are rapidly emerging as systems of choice. These
vectors protect NAs from enzymatic degradation by forming condensed
complexes along with targeted tissue and cellular delivery. During
the past few years, a myriad reports have appeared reporting
delivery of NAs mediated by nanoparticles. This book will provide
an overview of nanoparticles being employed in the in vitro and in
vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA,
PNA, etc.
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