Histoplasmosis is a fungal disease that is widely endemic in
much of the world. In the central United States, including the
broad reaches of the Ohio and Mississippi River valleys, the
majority of adults are infected with the causative fungus. Most
infected individuals handle this infection well, but a few do
become sick. Over the years there have been a number of outbreaks
or epidemics with many persons becoming severely ill and some dying
as a result. This is the story of the discovery of histoplasmosis
in 1905 and the subsequent development of knowledge concerning its
etiology, pathogenesis, epidemiology, diagnostic challenges,
clinical manifestations, and treatment. Uniquely qualified to tell
this tale, Daniel and Baum base their study on original source
material not previously available.
The story of histoplasmosis spans the twentieth century, from
its discovery by Samuel Taylor Darling in Panama to the development
of effective drug treatment near the century's end. The book
epitomizes the growth of medical knowledge through the confluence
of ideas and information arising from the work of many individual
investigators, a recurrent theme in the history of medicine. Daniel
and Baum include much original and previously unreported material
derived from BauM's direct involvement with the unraveling of the
pathogenesis of the disease and his personal knowledge of the
people and events detailed in this book.
General
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