The work presented in Thomas M. Gogsig's thesis deals with the
discovery of new metal-catalyzed transformations ranging from
Kumada-, Heck- and Suzuki-type reactions. The thesis starts with a
formidable introduction to Pd-catalyzed cross-coupling reactions.
New results have been obtained on:
(i) Pd-catalyzed 1,2-migration reactions,
(ii) Pd-catalyzed Heck reactions employing heteroaromatic
tosylates,
(iii) Ni-catalyzed Heck reactions, and
(iv) Pd-catalyzed carbonylative Heck reaction.
Metal-catalyzed cross-coupling reactions are today a highly
competititve field (the 2010 Nobel Prize in Chemistry was awarded
"for palladium-catalyzed cross couplings in organic synthesis," the
2001 and 2005 Nobel Prizes in closely related fields). Thomas M.
Gogsig obtained new results in his thesis that will help to improve
the outcome of catalytic processes and improve their scope. The
results will thus become key references for tomorrow's new
applications. All chapters include insightful discussions and
in-depth descriptions of the key principles of these new
discoveries."
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