A cutting-edge collection of readily reproducible molecular
techniques to better understand, classify, and treat lymphoma.
Among the highlights are methods to use immunoglobulin gene
rearrangements as markers of clonality, to exploit patterns of
somatic mutation in the variable regions to indicate at which stage
transformation occurred, and to apply gene arrays to the question
of biological heterogeneity in morphologically similar diseases.
Research methodologies that are highly likely to become routine
practice in the future, such as DNA microarray and immunoglobulin
V-gene rearrangements, and measurement of minimal disease, are
included. There are also molecular techniques for providing for
producing novel therapeutics, such as a DNA vaccine with
patient-specific sequences derived from the lymphoma in question.
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