Cardiovascular disease is the leading cause of morbidity and
premature death of modern era medicine. It is estimated that
approximately 81 million people in the United States (US) currently
have one or more of the many forms of cardiovascular disease,
resulting in 1 in every 2.8 deaths, or 900,000 deaths per year. 40%
of all deaths in Europe are a result of cardiovascular disease in
people under the age of 75. Aneurysms form a significant portion of
these cardiovascular related deaths and are defined as a permanent
and irreversible localised dilation of a blood vessel greater than
50% of its normal diameter. Although aneurysms can form in any
blood vessel, the more lethal aneurysms develop in the cranial
arteries, and in the thoracic aorta and abdominal aorta. Frequently
aneurysms are undetected and if left untreated may eventually
expand until rupture with very high levels of morbidity and
mortality. The biomechanics and mechanobiology of aneursymal
diseases are not fully understood and this monograph aims to
provide new insights into aneurysm aetiology and behavior based on
the most recent biomechanics research related to this important
topic. The contributors to this volume bring together a unique
blend of expertise in experimental, computational and tissue
biomechanics relating to aneurysm behavior and enable the reader to
gain a fresh understanding of the key factors influencing aneurysm
behavior and treatment. Biological risk factors such as tobacco
smoking, sex, age, hypertension, family history and
mechanobiological risk factors such as aneurysm geometry and shape
as well as mechanical properties of the diseased tissues are
considered in detail as are many of the diagnostic and treatment
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