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Blood Brain Barrier (Hardcover)
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Blood Brain Barrier (Hardcover)
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The blood-brain barrier (BBB) is a membranic structure that acts
primarily to protect the brain from chemicals in the blood, while
still allowing essential metabolic function. It is composed of
endothelial cells, which are packed very tightly in brain
capillaries. This higher density restricts passage of substances
from the bloodstream much more than endothelial cells in
capillaries elsewhere in the body. Astrocyte cell projections
called astrocytic feet (also known as "glia limitans") surround the
endothelial cells of the BBB, providing biochemical support to
those cells. The BBB is distinct from the similar
blood-cerebrospinal fluid barrier, a function of the choroidal
cells of the choroid plexus, and from the Blood-retinal barrier,
which can be considered a part of the whole (the retina of the eye
is an extension to the central nervous system and as such, can be
considered part of the BBB).
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