This book covers wide areas of animal and human psychopharmacology
with clinical utility in the treatment of psychiatric and
neurological (e.g Alzheimer's disease) disorders. The main theme is
to develop a new paradigm for drug discovery that questions the
claim that animal models or assays fail adequately to predict Phase
3 clinical trials. A new paradigm is advocated that stresses the
importance of intermediate staging points between these extremes
that depend on suitable translation of findings from animal studies
to Phase 1 or Phase 2 studies utilising experimental medicine.
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