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Biochemical assessment of drugs active pharmaceutical ingredients (Paperback)
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Biochemical assessment of drugs active pharmaceutical ingredients (Paperback)
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The Active Pharmaceutical Ingredients (API) is functional
ingredients of a drug that acts against diseases. In other words,
the active ingredient(s) in a drug or medicine are the substances
that produce intended pharmacologic effects which might be positive
or negative. The quality and safety of the drugs depends on API and
new chemical entity development entirely depends on it. Most of the
pharmaceutical industries buy API from other manufacturing units.
Therefore, it becomes mandatory to check quality of APIs and other
raw materials. In the present study, assessment of the level of
APIs in local drugs and microbial quality of water used in
Pakistani pharmaceutics were studied. The present study found that
twelve (n=12) drugs being analyzed for their APIs concentration
were within acceptable level. These drugs include mefenamic acid,
pyrental pamoate, lignocaine hydrochlorid, ephedrine hydrochloride,
cimetidine, aspirin, metronidazole, salbutamol, sulphamethoxazole,
trimethoprim, benzyl benzoate and dexamethasone.The obtained
results were statistical different for different drugs (P 0.05).
However, no significant differences were found within drugs
groups."
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