A critical review our current understanding of camptothecins, their
shortcomings, and of the possibilities for improving their clinical
performance. The authors discuss new camptothecin analog
development, drug delivery issues for optimizing their anticancer
activity, and their potential use in a variety of different
cancers. Additional chapters describe what is known about the
biochemistry, the pharmacology, and the chemistry of the
camptothecins, including the mechanism of topoisomerase and how
camptothecins poison this enzyme, the use of animal models in
defining the anticancer potential of camptothecins, and the
question of camptothecin resistance.
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