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Sumoylation - Molecular Biology and Biochemistry (Hardcover)
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Sumoylation - Molecular Biology and Biochemistry (Hardcover)
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The Horizon Bioscience series focuses on high-level microbiology
and molecular biology topics. Written by internationally renowned
and highly respected leaders in the field, titles in this series
comprise of review manuals, practical manuals, and reference texts
for research scientists, bioscience professionals and graduate
students. Sumoylation is a novel posttranslational modification
system, biochemically analogous to, but functionally distinct from,
ubiquitinylation. Sumoylation involves the covalent attachment of a
SUMO (small ubiquitin-related modifier) to substrate proteins. This
modification system has crucial roles in many different biological
processes, including protein localization and stability,
transcriptional activities, nucleocytoplamic signalling and
transport, and genome replication, as well as the regulation of
gene expression. The molecular and biochemical mechanisms involved
in sumoylation have been the subject of intense interest in recent
years. This volume, edited and written by leading international
experts, is the first book to be devoted to sumoylation. It
presents information on the history, evolution and mechanisms of
sumoylation, discusses SUMO proteases, ligases and conjugation
pathways, and reviews the impact on modification and
nucleocytoplasmic transport, PML nuclear bodies, and
transcriptional regulation. In addition, specialist chapters cover
the role of sumoylation in yeast, viruses and the tumor suppressor
P53. This comprehensive book is the definitive reference volume on
all aspects of sumoylation. It is an essential reference manual for
all researchers in this area.
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