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Mouth Dissolving Tablet of Olanzapine by Solid Dispersion Technique (Paperback)
Loot Price: R1,460
Discovery Miles 14 600
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Mouth Dissolving Tablet of Olanzapine by Solid Dispersion Technique (Paperback)
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Total price: R1,480
Discovery Miles: 14 800
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In the present investigation, solid dispersion of olanzapine has
been prepared to improve its solubility. Further, using solid
dispersion, mouth dissolving tablet was prepared to overcome the
problem of swallowing. A Simplex Lattice design was applied using
three factors, i.e. superdisintegrants like croscarmellose
sodium(X1) crospovidone(X2), and sodium starch glycolate(X3) in
tablet formulation. Disintegration time, Wetting time, Water
absorption, T50 (Time required to 50% drug release) and Q10
(percentage of drug released in 10 min.) taken as responses. Solid
dispersion showed significant enhancement in solubility of
olanzapine. For mouth dissolving tablet, batch containing 5%
croscarmellose sodium alone had minimum disintegration time (44
sec.) and faster drug release(T50: 40 sec) compared to other
batches.
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