Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
|
Buy Now
Regulators and Effectors of Small GTPases: Rho Family, Volume 406 (Hardcover, 406th edition)
Loot Price: R4,211
Discovery Miles 42 110
|
|
Regulators and Effectors of Small GTPases: Rho Family, Volume 406 (Hardcover, 406th edition)
Series: Methods in Enzymology
Expected to ship within 12 - 17 working days
|
The Ras superfamily (>150 human members) encompasses Ras GTPases
involved in cell proliferation, Rho GTPases involved in regulating
the cytoskeleton, Rab GTPases involved in membrane targeting/fusion
and a group of GTPases including Sar1, Arf, Arl and dynamin
involved in vesicle budding/fission. These GTPases act as molecular
switches and their activities are controlled by a large number of
regulatory molecules that affect either GTP loading (guanine
nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase
activating proteins or GAPs). In their active state, they interact
with a continually increasing, functionally complex array of
downstream effectors.
Since the last Methods in Enzymology volume on this topic in 2000,
Rho GTPases have continued to receive a huge amount of attention.
The human genome sequence has revealed the full extent of the Rho
GEF and Rho GAP families (over 80 members for each) and the
challenge of identifying the molecular interactions and cellular
pathways influenced by each of these regulators is a daunting
prospect. This new volume describes some of the methods currently
being used to examine Rho family GTPase regulation at the
biochemical and cellular level.
*Describes the methods currently being used to examine Rho family
GTPase regulation at the biochemical and cellular levels.
*Includes new imaging techniques that revolutionize the ability to
visualize GTPase activities.
*Over 150 international contributors.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
|
|
Email address subscribed successfully.
A activation email has been sent to you.
Please click the link in that email to activate your subscription.