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Regulators and Effectors of Small GTPases: Ras Family, Volume 407 (Hardcover, 407th edition)
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Regulators and Effectors of Small GTPases: Ras Family, Volume 407 (Hardcover, 407th edition)
Series: Methods in Enzymology
Expected to ship within 12 - 17 working days
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The Ras superfamily (>150 human members) encompasses Ras GTPases
involved in cell proliferation, Rho GTPases involved in regulating
the cytoskeleton, Rab GTPases involved in membrane targeting/fusion
and a group of GTPases including Sar1, Arf, Arl and dynamin
involved in vesicle budding/fission. These GTPases act as molecular
switches and their activities are controlled by a large number of
regulatory molecules that affect either GTP loading (guanine
nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase
activating proteins or GAPs). In their active state, they interact
with a continually increasing, functionally complex array of
downstream effectors.
Since the last Methods in Enzymology volume on this topic in 2000,
the study of Ras Family GTPases has witnessed a plethora of new
directions and trends. With regards to the founding member of the
Ras superfamily, the study of Ras in oncogenesis has seen the
development and application of more advanced model cell culture and
animal systems. The discovery of mutationally activated B-Raf in
human cancers has injected renewed interest in this classical
effector pathway of Ras.
*Includes a database for Ras family proteins and their effectors
and regulators
*Complimentary to volume 406 coverage of the Rho family
*Over 150 international contributors
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