Breast cancer continues to be the focus of intense basic and
clinical research. In Valurne 1 of this series we dealt exclusively
with topics concerned with therapy. In the present Valurne 2, we
turn our attention to the experimental biology which is the
foundation for our understand ing of problems concerned with breast
cancer etiology, mechanisms of hormone action, cell kinetics,
experimental chemotherapy, and markers of tumor burden. The
contributors to the volume are all noted scholars who are
personally investigating these problems. The first chapter
addresses the question, do hormones cause breast cancer? Segaloff
provides us with a rational up-to-date overview of the existing
data. He concludes that hormones by themselves are not tumor
initiators but rather alter the hast environment so that other
carcinogens are effective. lt is pointed out that the selection of
the modeltest system is critical; one can almost assure any desired
result by choosing an ap propriately biased test system. The
question of the role of viruses in the etiology of human breast
cancer remains unanswered despite elegant studies in mause systems.
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