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Quantification of Circulating Proteins - Theory and applications based on analysis of plasma protein levels (Paperback, Softcover reprint of the original 1st ed. 1982)
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Quantification of Circulating Proteins - Theory and applications based on analysis of plasma protein levels (Paperback, Softcover reprint of the original 1st ed. 1982)
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Less than 50 years ago it was discovered that steady-state protein
concentrations in plasma are the net result of continuous
elimination and synthesis of protein molecules. The first quanti
tative studies on the turnover and distribution of plasma pro teins
were made around 1950, after the introduction of radio labeled
protein preparations. Around 1970, another development in
quantitative interpre tation of circulating proteins was initiated
in clinical enzy mology. Estimation of cumulative release into
plasma of cellular enzymes can be helpful in a variety of diseases
to assess the extent of tissue damage and to evaluate therapy.
Enzymes can be considered as biological tracers, i.e. minute
quantities of protein can be accurately determined by their spe
cific catalytic activities. However, radioactive tracers permit
direct estimates of turnover and distr ibution by measurement of
excreted radioactivity, possibilities that are not available for
enzymes. Consequently, only a few techniques used in tracer studies
with radiolabeled proteins can be applied to circulating tissue
enzymes and this may explain the lack of communication between the
fields of plasma protein metabolism and quantitative clinical
enzymology. In the present study a summary is given of the basic
methods used in both fields, with emphasis on the equivalence of
various models and formalisms used by different authors. It is
shown that major limitations in the study of circulating tissue
enzymes can be overcome if two different, but simultaneously
released, en zymes can be measured. The resulting method will also
be applied to plasma protein metabolism."
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