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Books > Science & Mathematics > Biology, life sciences > Human biology & related topics
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Integrative Physiology in the Proteomics and Post-Genomics Age (Hardcover, 2005 ed.)
Loot Price: R3,006
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Integrative Physiology in the Proteomics and Post-Genomics Age (Hardcover, 2005 ed.)
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There is a perception in the scientific community that the
discipline of Physiology is in crisis, or at least, in a phase of
profound transition and change. At the root of the problem is
confusion between objectives (the biological questions to be
solved) and the methods and technologies to be applied.
Traditionally, ever since Claude Bernard's concept of the "milieu
interieur," Physiology was an integrative science with the prime
concern of studying regulatory mechanisms leading to adaptation and
homeostasis in the presence of challenges from a dynamic internal
and external environment. This study of control mechanisms can be
applied on any level of fu- tion whether subcellular, cellular, and
organ, but reaches its highest level of complexity with the
functioning of the body as a whole and its interaction with the
external environment. This involves the determination of the
interaction of genetic with environmental factors and the resulting
integrated body adaptation. It might seem obvious that in the
pursuit of these questions any appropriate combination of
techniques on any organizational level could be used. Yet the
advent of molecular techniques has resulted in a preoccupation with
the problems and challenges inherent in these techniques, sometimes
at the expense of the original perspectives and concepts. The many
new mechanisms that have been discovered at the molecular level, as
well as their economical exploitation, have contributed to a
climate of reductionism.
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