Kinesins form a large microtubule-associated motor protein
super-family that can be found in every eukaryotic genome sequenced
so far. Not only is the translocation of a large number of
organelles, protein complexes and mRNAs carried out by them, but
also the formation of the meiotic spindle and mitotic spindle
integrity are strongly dependent on the kinesins. To understand the
kinesins, we have to answer many questions, such as how many
sub-families are there in kinesin super-family; what is the
commonesses and differences among kinesin sub-families; how to
classify kinesins and determine the sequence and strutural factors
that are responsible for functions. These are basic questions but
not answerable until one gets enough data. Thanks for the new
sequencing technology, there are more than 2000 kinesins available,
which makes it possible to address these questions with
bioinformatic methods now.
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