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Books > Medicine > Other branches of medicine > Medical imaging
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Multiparametric Imaging in Neurodegenerative Disease (Hardcover)
Loot Price: R3,219
Discovery Miles 32 190
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Multiparametric Imaging in Neurodegenerative Disease (Hardcover)
Expected to ship within 12 - 17 working days
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Neuroimaging techniques that can help elucidate and characterize
the nature and mechanism of tissue injury and disease progression
in neurodegenerative disease are of particular importance given its
their roles in seeking successful preventive and therapeutic
treatments. Studying large-scale samples with various disease
mechanisms using multi-parametric imaging, as well as revealing the
correlations between the neuroimaging metrics and clinical data
including neurocognitive function and neuropsychological
inventories to elucidate multiple factors affecting the
neurodegeneration processes in brain are the main topics of this
book. In addition, the neural underpins of cognitive and
psychological functions with advanced functional imaging techniques
can provide better cross-validation and clinical symptom relevance
of multi-parametric data. Expanding the current findings with
higher diagnosis accuracy and detection specificity in multiple
neurodegenerative diseases as well as better differentiation of
each type are the ultimate goal. The results in this book will
extend the current notion of diagnosis value of various relatively
new imaging techniques in multiple neurodegenerative diseases
including traumatic brain injury, post-traumatic stress disorder,
multiple sclerosis and early stage of Alzheimer's disease such as
mild cognitive impairment. Specifically, the neurobiology and
related imaging findings of the four representative
neurodegenerative diseases will be introduced and reviewed,
including brain region-specific and disease-related alterations,
unique clinical symptom of each disease, as well as previous
findings and challenges. There is an increasing body of literature
suggesting that damage to the default mode network, hypothalamus,
thalamus and hippocampus neuronal networks and local injuries might
be under-diagnosed and may account for some of the sequelae
following the neurodegenerative injuries including trauma and
dementia. The relatively novel imaging results to differentiate
each disease using advanced functional connectivity, neuronal
activity, microstructure integrity analysis based on structural
connectivity, multi-dimensional morphometry and molecular imaging
tracers including amyloid and tau for neuropathological burden
quantification were presented to differentiate each type of
disease. We then briefly reviewed some of the therapeutic effects
of traditional Chinese medicine with neuroimaging quantifications
to help treating neurodegenerative diseases. Finally, our work
proves that the multi-parametric neuroimaging methods with more
than twelve metrics and numerous tight clinical association data
presented in this book are the most forefront and up-to-date with
enough sensitivity, precision and resolution. Taken together,
multiple neuroimaging metrics haved been demonstrated in this book
to identify and quantify significant and distinct brain alterations
at function, microstructure, morphology and molecular scales in
different types of neurodegenerative diseases with high sensitivity
and specificity. These comprehensive imaging features could be
combined to improve disease diagnosis accuracy. The aim of this
book is thus intended to provide both beginners and experts in
biomedical imaging and health care a broad and complete picture as
well as the new developments of using multiple metrics in improving
disease identification and diagnosis accuracy. This book would
hopefully capture the interests of colleagues interested in
neurodegenerative disease diagnosis and treatment, and could help
convey the methodological and integrative perspectives of
multi-parametric neuroimaging applications.
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