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Neurobiology of DOPA as a Neurotransmitter (Hardcover)
Loot Price: R6,249
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Neurobiology of DOPA as a Neurotransmitter (Hardcover)
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New research suggests it is highly probable that DOPA, in addition
to being a precursor to dopamine, functions by itself as a
neurotramsmitter and/or neuromodulator. Neurobiology of DOPA as a
Neurotransmitter integrates background information about DOPA as an
inert amino acid precursor of dopamine with the evidence showing
that DOPA fulfills several criteria of neurotransmitters. Providing
easy access to, and complete understanding of, the latest research
on the subject, the book makes the case that DOPA meets many of the
criteria of neurotransmitters and includes anti-evidence in some
instances. The book begins with a historical review of current
knowledge of DOPA. It characterizes DOPA as a prominent example
showing transmutation from an inert substance to a gold drug in
Parkinson's disease and further to a neurotransmitter in its own
right. The next chapters cover the essential criteria of a
neurotransmitter such as synthesis, existence, and competitive
antagonism. The book describes metabolism composed of catecholamine
synthesis and degradation products related to neuron death,
physiological release of DOPA in the lower brainstem, striatum, and
nucleus accumbens, and physiological or pharmacological responses
involved in baroreflex neurotransmission and related to behavioral
science including interactions with catecholamines, acetylcholine,
glutamate, and GABA. The book explores recognition sites, transport
sites, and therapeutic role and mechanisms for neuron death related
to adverse influence in the treatment of Parkinson's Disease.
Edited by experts in the field, the breadth and depth of
information contained in this book is confirmed by a quick scan of
the chapter authors. Theysummarize the issues surrounding DOPA
neurotoxicity and explore the link between experimental studies and
clinical relevance.
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