Diabetes Mellitus - A risk factor for Alzheimer's Disease (Hardcover, 1st ed. 2019)

This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer's disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.

General

Imprint:	Springer Verlag, Singapore
Country of origin:	Singapore
Series:	Advances in Experimental Medicine and Biology, 1128
Release date:	May 2019
First published:	2019
Editors:	Yusaku Nakabeppu • Toshiharu Ninomiya
Dimensions:	235 x 155mm (L x W)
Format:	Hardcover
Pages:	248
Edition:	1st ed. 2019
ISBN-13:	978-981-13-3539-6
Categories:	Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology Books > Medicine > Clinical & internal medicine > Endocrinology > Diabetes Books > Medicine > Other branches of medicine > Pathology > Gross pathology
LSN:	981-13-3539-7
Barcode:	9789811335396

Is the information for this product incomplete, wrong or inappropriate? Let us know about it.

Does this product have an incorrect or missing image? Send us a new image.

Is this product missing categories? Add more categories.

Review This Product

No reviews yet - be the first to create one!