Benzyl-o-vanillin and benzimidazole nucleus serves as an important
pharmacophore in drug discovery as it have a significant medicinal
importance. Thus we explored the anticancer activity of three
relative compounds and found their structure activity relationship
compare with 2-benzyloxy-3-methoxybenzaldehyde main structure.
According to the cytotoxicity analysis, they induce cell death of
leukemic cell line through DNA fragmentation. DNA binding studies
reveals that the DNA binding occurs through groove region. The
higher mutagenicity might cause DNA mutation through interaction
with the guanines while the lack of significant mutagenic activity
suggests that the compound may target mainly the AT rich sequences
of the nucleic acid. Hence, the present study provides a new
insight of these novel (2-benzyloxy-3-methoxyphenyl) derivatives
serving as a potential therapeutic agent against leukemia. This
work should help shed some light on these exciting compounds and
their SAR results, and should be especially useful to professionals
in Oncology and cancer research feilds, or anyone else who may be
considering utilizing DNA-drug interactions along with mutagenicity
for research effort.
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