Sit back, relax and enjoy the ride!

In Bullet Train, Brad Pitt stars as Ladybug, an unlucky assassin determined to do his job peacefully after one too many gigs gone off the rails. Fate, however, may have other plans, as Ladybug's latest mission puts him on a collision course with lethal adversaries from around the globe – all with connected, yet conflicting, objectives – on the world's fastest train... and he's got to figure out how to get off.

The end of the line is only the beginning in a wild, non-stop thrill ride through modern-day Japan.

Joey Evans has always loved bikes, from his first second-hand Raleigh Strika at the age of six to the powerful off-road machines that became his passion later on in his life. His dream was one day to ride the most gruelling off-road race in the world, the 9000km Dakar Rally. In 2007 his dream was shattered when he broke his back in a racing accident. His spinal cord was crushed, leaving him paralysed from just below his chest. Doctors gave him a 10 per cent chance of ever walking again. Many would have given up and become resigned to life in a wheelchair, but not Joey Evans.

Not only would he get back on his feet and walk, but he would also keep his Dakar dream alive. It was a long and painful road to recovery, involving years of intensive rehabilitation and training, but he had the love and support of both family and friends and an incredible amount of determination. Joey shares the many challenges he and his family faced, relating the setbacks, as well as successes, along the way to the Dakar start line. But the start line was only the first goal – his sights were set on reaching the finish line, which he did in 2017 – the only South African to do so.

From Para To Dakar is so much more than the story of one man reaching the Dakar finish line. It is a story of friendship and respect, compassion and kindness. It is about defying the odds to reach a dream, it is about grit, endurance and raw courage, and it is inspiring in its true heroism.

Musical drama in which a pair of aspiring musicians with unglamorous day jobs team up in a bid to find success. Nate (Alec Newman) works in the financial services industry during the day, identifying struggling companies in order to bet against them on the stock market and bring home profit. Aware of the job's inherent unpleasantness, he seeks refuge at night playing the piano and in his dreams of life as a professional musician. One night, while playing his music, he hears someone singing along on the street outside. It turns out to be Chloe (Amy Adams), a cloakroom worker from the nearby jazz club who also dreams of a better life. Recognising the beauty of Chloe's voice, Nate suggests that the pair marry their talents and become a musical duo. Will their musical relationship develop into something more?

Dive deep into the world of Netflix’s Outer Banks with this official guide to the hit show Uncover never-before-told stories in the only official insider fan guide to the hit Netflix series Outer Banks. Designed as a scrapbook pieced together by John B, JJ, Kiara, Pope, and Sarah, this deluxe, full-color collectable edition features a removable jacket and is packed with exclusive content including photos, secret pages from Big John’s journal, surfer profiles, insights on local legends, and much more. Pore over every detail of the Pogues’ wild summer for the ultimate immersive experience of life in the Outer Banks. Includes a bonus Episode Guide to the first two seasons!

Step through the wardrobe and learn your numbers from one to ten in this counting adventure based on The Lion, the Witch and the Wardrobe!

This bright and engaging board book introduces young readers to all the magic of C. S. Lewis’s world of Narnia.

All the best bits from series 1-9 of the comedy panel game show. Along with all the clips that were too rude for TV, the show features host Keith Lemon, team captains Holly Willoughby and Fearne Cotton and guest appearances from, among others, Dermot O'Leary, Davina McCall, Ant and Dec, JLS, Kelly Brook, Jason Manford, Mo Farah and The Wanted.

Journey into Narnia and meet animals of all kinds in this animal adventure!

This bright and engaging board book introduces young readers to all the magic of C. S. Lewis’s world of Narnia.

The lymphatic system develops and functions in parallel with the blood circulatory system (termed the "hemovasculature") and accomplishes transport of interstitial fluids, dietary lipids, and reverse transport of cholesterol, immune cells, and antigens-providing a critical homeostatic fluid balance and transmission of immune cells and mediators back to the cardiovascular system. Although the daily flow of lymph (normally 1-2 L/day under unstressed conditions) is far lower than that of daily blood flow (which is 7,500 L/day), without the adequate functioning of the lymphatics, virtually all organs and tissues would acutely suffer many different physical and inflammatory stresses ranging from edema to organ system failure. Although blood and lymphatic vessels often form in anatomic parallels to one another, our knowledge of the workings of the lymphatic system, the fine structure of lymphatic networks, how they function in different organs, and how they are regulated physiologically and immunologically are far from parallel; our knowledge of the lymphatic system still remains at only a tiny fraction of what is understood about the cardiovascular system. Although both the cardiovascular and lymphatic systems are important transport systems, what they transport and how they transport and propel these very different cargoes could not be more dissimilar. This book provides an overview of the history of the discovery (and re-discovery) of the components of the lymphatic system, lymphatic anatomy, physiological functions of lymphatics, molecular features of the lymphatic system, and clinical perspectives involving lymphatics which may be of interest to scientists, clinicians, patients, and the lay public. We provide a current understanding of some of the more important structural similarities and differences between lymphatics and the blood vascular system, their coordinated control by angiogenic and hemangiogenic growth factors and other modulators, the fate and lineage determinants which control lymphatic development, and the roles that lymphatics may play in several different diseases.

This collaboration of two physiologists and a gastroenterologist provides medical and graduate students, medical and surgical residents, and subspecialty fellows a comprehensive summary of digestive system physiology and addresses the pathophysiological processes that underlie some GI diseases. The textual approach proceeds by organ instead of the traditional organization followed by other GI textbooks. This approach lets the reader track the food bolus as it courses through the GI tract, learning on the way each organ's physiologic functions as the bolus directly or indirectly contacts it. The book is divided into three parts: (1) Chapters 1-3 include coverage of basic concepts that pertain to all (or most) organs of the digestive system, salivation, chewing, swallowing, and esophageal function, (2) Chapters 4-6 are focused on the major secretory organs (stomach, pancreas, liver) that assist in the assimilation of a meal, and (3) Chapters 7 and 8 address the motor, transport, and digestive functions of the small and large intestines. Each chapter includes its own pathophysiology and clinical correlation section that underscores the importance of the organ's normal function.

Environmental heat stress is associated with a marked decrease in orthostatic tolerance (OT), which is defined as the ability to stand or sit upright without symptoms of dizziness, lightheadedness, presyncope, or fainting. In most healthy humans, the autonomic nervous system makes rapid and balanced adjustments to heart rate and peripheral blood flow, such that most people are able to stand up "successfully" most of the time, in most environments. The goal of this book is to discuss various aspects of the sympathetic neural response to heat stress, how the sympathetic nervous system coordinates the successful integrative physiological response to orthostasis, and what happens when it encounters both challenges simultaneously. We include overviews of mechanisms of thermoregulation and blood pressure regulation in humans, with particular focus on control of cardiac output and neurovascular control mechanisms during heat stress. We discuss the implications that these changes have for distribution of peripheral blood flow and, in particular, for blood flow to the cerebral circulation. The added stressor of dehydration is also discussed, as it so often goes hand in hand with heat stress. We end with a brief presentation of countermeasures against the decreases in OT with heat stress.

The kidney is innervated with efferent sympathetic nerve fibers reaching the renal vasculature, the tubules, the juxtaglomerular granular cells, and the renal pelvic wall. The renal sensory nerves are mainly found in the renal pelvic wall. Increases in efferent renal sympathetic nerve activity reduce renal blood flow and urinary sodium excretion by activation of 1-adrenoceptors and increase renin secretion rate by activation of 1-adrenoceptors. In response to normal physiological stimulation, changes in efferent renal sympathetic nerve activity contribute importantly to homeostatic regulation of sodium and water balance. The renal mechanosensory nerves are activated by stretch of the renal pelvic tissue produced by increases in renal pelvic tissue of a magnitude that may occur during increased urine flow rate. Under normal conditions, the renal mechanosensory nerves activated by stretch of the sensory nerves elicits an inhibitory renorenal reflex response consisting of decreases in efferent renal sympathetic nerve activity leading to natriuresis. Increasing efferent sympathetic nerve activity increases afferent renal nerve activity which, in turn, decreases efferent renal sympathetic nerve activity by activation of the renorenal reflexes. Thus, activation of the afferent renal nerves buffers changes in efferent renal sympathetic nerve activity in the overall goal of maintaining sodium balance. In pathological conditions of sodium retention, impairment of the inhibitory renorenal reflexes contributes to an inappropriately increased efferent renal sympathetic nerve activity in the presence of sodium retention. In states of renal disease or injury, there is a shift from inhibitory to excitatory reflexes originating in the kidney. Studies in essential hypertensive patients have shown that renal denervation results in long-term reduction in arterial pressure, suggesting an important role for the efferent and afferent renal nerves in hypertension.