The author of the multi-prize-winning The Year of the Runaways returns with a novel of forbidden love that echoes across the generations 'China Room is the kind of novel that reminds you why you fell in love with reading' Open Book, BBC Radio 4 Shortlisted for the Rathbones Folio Prize 2022 Longlisted for the Booker Prize 2021 Longlisted for the Walter Scott Prize for Historical Fiction 2022 Longlist for the Ondaatje Prize 2022 A Daily Telegraph , Guardian and The Times Book of the Year Mehar, a young bride in rural 1929 Punjab, is trying to discover the identity of her new husband. She and her sisters-in-law, married to three brothers in a single ceremony, spend their days at work in the family's 'china room', sequestered from contact with the men. When Mehar develops a theory as to which of them is hers, a passion is ignited that will put more than one life at risk. Spiralling around Mehar's story is that of a young man who in 1999 travels from England to the now-deserted farm, its 'china room' locked and barred. In enforced flight from the traumas of his adolescence - his experiences of addiction, racism, and estrangement from the culture of his birth - he spends a summer in contemplation and recovery, finally gathering the strength to return home. Readers love CHINA ROOM: ***** Amazing... I could not put it down! ***** The characters jump off the pages... Beautiful ***** Powerful and heart-wrenching ***** Wonderful... I read it in one sitting ***** Gripping storytelling... An easy five stars

Following the success of his first book, The Shotokan Karate Handbook -- Beginner to Black Belt, the author felt there was a need for a manual to assist the more experienced student. Therefore, he has concentrated on more advanced techniques such as Kihon lppon Kumite, Jiyu lppon Kumite sets 6 and 7, and all the remaining Katas in Shotokan Karate. It is important that Karate Ka are aware that time, effort and practice are still the main factors in working towards perfecting not only one's skills but also one's inner mind and attitudes towards the art. This book is meant as a guide to Karate Ka -- it cannot take the place of your Sensei (teacher).

There have been numerous books written on the subject of Karate, including many that claim to show an easy, step-by-step, way of becoming a black belt by the third chapter. In a martial art such as Karate, it is extremely rare to find a book that can help the student with the physical aspect of Karate to any great degree. However, every now and then a publication appears on the bookstands that can do just that. One such book is this one. The following pages contain a wealth of information on the Kihon, Kata, and Kumite aspects of Traditional Shotokan. Written in an easy to follow manner, and supplemented by an extremely comprehensive set of photographs, this handbook is easily one of the more superior publications available.

A political satire relevant for today, delaing with capitalism, poverty and greed, with greedy cats and hungry rats, that teaches children about the impact of what happens when people take a great deal more than they need. "A work or satirical genius," says Chicken and Frog bookshop.

The second volume in the CURRENT TOPICS IN NONCLINICAL DRUG DEVELOPMENT SERIES explores the critical issues and current topics in nonclinical drug development. This second volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed. Select topics include: Evolution of Artificial Intelligence (AI) technologies and the impact on toxicologic pathology. Current approaches to carcinogenicity testing. Predicting drug-drug interactions Current understanding of idiosyncratic drug reaction. Assessing cardiovascular risks beyond QT interval. Use of 3-D cell cultures in toxicology and ADME. Development of small molecule-antibody complexes. Differentiating adverse from non-adverse finding is nonclinical studies. Current Topics in Nonclinical Drug Development: Volume 2 will aid toxicologists, toxicologic pathologists, consultants, regulators, Study Directors, and nonclinical scientists dealing with day-to-day issues encountered in drug development and assist in formulating strategies for resolution of these issues. In addition, the book will be a valuable reference for academicians and graduate students pursuing research related to nonclinical drug development.

Written in an accessible style from a consumer perspective and blends academic research with professional insights. Deals with all essential aspects of financial services that affect consumers and how they can exploit opportunities. Each of the chapters contain a list of learning objectives; a range of scenarios, case studies, examples and articles to provide a "real world" context to the discussion; a key points summary with referencing and further reading and useful on-line resources, as well as, a selection of short self-review questions. Enables readers to understand how the operations, complexity and dynamism of an ever-changing financial services industry shape the financial opportunities and risks they face.

Written in an accessible style from a consumer perspective and blends academic research with professional insights. Deals with all essential aspects of financial services that affect consumers and how they can exploit opportunities. Each of the chapters contain a list of learning objectives; a range of scenarios, case studies, examples and articles to provide a "real world" context to the discussion; a key points summary with referencing and further reading and useful on-line resources, as well as, a selection of short self-review questions. Enables readers to understand how the operations, complexity and dynamism of an ever-changing financial services industry shape the financial opportunities and risks they face.

The inaugural volume in the Current Topics in Nonclinical Drug Development Series explores the critical issues and current topics in nonclinical drug development. This first volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed. Additional features include: Deals with day-to-day issues in study design, evaluation of findings, and presentation of data. Explains new approaches in the development of medical devices. Includes dedicated chapters on the use of bioinformatics in drug development. Addresses strategies for photosafety testing of drugs. Current Topics in Nonclinical Drug Development, Volume I will aid toxicologists, toxicologic pathologists, consultants, regulators, Study Directors, and nonclinical scientists dealing with day-to-day issues in study design, evaluation of findings, and presentation of data. In addition, the book will be a valuable reference for academicians and graduate students pursuing research related to nonclinical drug development.

Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk. Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions. The 13 organ system chapters provide the specifics related to pathologic characteristics, differential diagnosis, and interpretation of toxic responses in each organ system. These chapters are specifically important for the bench pathologist but also for the toxicologist who interacts with pathologists and function as study toxicologists and project team representatives in the drug development arena.

Shortlisted for the Man Booker Prize 2015 Sweeping between India and England, and between childhood and the present day, Sunjeev Sahota's unforgettable novel about illegal immigrants is - as with Rohinton Mistry's A Fine Balance - a story of dignity in the face of adversity and the ultimate triumph of the human spirit. 'The Grapes of Wrath for the 21st century' - Washington Post The Year of the Runaways tells of the bold dreams and daily struggles of an unlikely family thrown together by circumstance. Thirteen young men live in a house in Sheffield, each in flight from India and in desperate search of a new life. Tarlochan, a former rickshaw driver, will say nothing about his past in Bihar; and Avtar has a secret that binds him to protect the chaotic Randeep. Randeep, in turn, has a visa-wife in a flat on the other side of town: a clever, devout woman whose cupboards are full of her husband's clothes, in case the immigration men surprise her with a call. 'A brilliant and beautiful novel' - author of Home Fire, Kamila Shamsie, Guardian

Disrupt your industry, boost profitability, and grow your business with a powerful A.I. strategy. Artificial Intelligence (A.I.) is on the verge of disrupting every domain of human existence. What does that mean for your business? Everything. Building on the power of A.I. is the factor that will determine success or failure in the very near future-and this in-depth guide from the man who designed the A.I. system that famously won Jeopardy provides everything you need to be a leader in this revolution. Own the A.I. Revolution provides a future-forward look at A.I.-how it will look in the coming years, the countless business opportunities it will offer, the risks that come with it-and delivers the knowledge you need to navigate it all in real and practical ways. You'll learn how to: *Find the right off-the-shelf A.I. solutions for your needs*Perform a cost/benefit analysis of implementing A.I. into your business strategy*Train and test A.I. before fully committing*Assemble superior teams to steer your A.I. future*Ensure you remain current and ahead of the curve You'll also find interviews with today's top experts and A.I. thought leaders on the exciting ways organizations are already transforming themselves through this revolutionary technology. A.I. sounds scary to some, but the best business leaders see it as an opportunity-as a way not only to drive profits and outpace the competition, but to build value for customers and make the world a better place. It's time to face our brave new A.I.-driven world-and make sure you Own the A.I. Revolution!

There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicology Pathology and Safety Science (IDTP) that this dictionary aims to fill. The language of toxicologic pathology may be less familiar to a broad range of safety scientists, especially those involved in the safety evaluation of pharmaceuticals and chemicals. The IDTP format provides the brevity and clarity that the user is not likely to receive in a textbook, even if adequately indexed. With the inclusion of descriptions for terms used in toxicology, drug metabolism/pharmacokinetics, and regulatory science, the scope of the IDTP is considerably broadened and decidedly unique in its appeal to all safety scientists. With over 800 photos and illustrations to provide visual context,* an important aim of the IDTP is to present pathological changes as reference examples for terminology, nomenclature, and term descriptions for the entry entry-level as well as seasoned toxicologic pathologist. It will also aid students and non-pathology specialists such as study directors, senior toxicology report reviewers, scientific management of contract research organizations, regulatory agencies, and drug development companies to better understand the biological significance of tissue changes. The IDTP provides a single reference volume for these users to further their understanding and appreciation of biologically significant pathology findings. The IDTP consists of four major areas: 1. A-Z Dictionary of Pathology encompassing all organ systems, together with relevant non-pathology terms supported by references in "For Further Reading" sections. 2. Appendix 1: An Overviews of Drug Development, Nonclinical Safety & Toxicologic Pathology, and Important/Special Topics. 3. Appendix 2: Diagnostic Criteria of for Proliferative Proliferative Lesions in Rodents (Rat and Mouse) and Selected Non-Rodent Laboratory Species containing illustrations with detailed references and links to source material. 4) Appendix 3: Mini-Atlas of Organ System Anatomy and Histology to help re-acquaint the non-pathologist safety scientist with many normal anatomical structures. The editors and contributing scientists (board-certified veterinary pathologists, board-certified toxicologists, allied health safety scientists, health regulatory representatives) have experience from bench-level pathology and toxicology to managing global preclinical safety units in leading pharmaceutical companies. They have considerable experience mentoring pharmaceutical industry project team members, interacting with industry clinicians and representatives of decision-making bodies within the industry, as well as with global health authorities, such as the FDA and EMA. These activities convinced them of the necessity for and usefulness of the IDTP. As experts in their field, they have undertaken the hard work of writing and compiling the information, making the IDTP an exceptional, go-to reference. *Illustrations Editor: Gregory Argentieri

Sustainability has come to the fore in the cosmetics and personal care industry. Rising ethical consumerism and the need for resource efficiency are making cosmetic companies small, independent firms to global giants take steps towards sustainable development. Sustainability: How the Cosmetics Industry is Greening Up discusses the growing importance of sustainability in the cosmetics industry, highlighting the various ways organisations can address the economic, environmental and social aspects. How can the cosmetics industry make a difference in terms of ingredients, formulations, packaging, CSR, operations, and green marketing? Topics covered include: * Environmental and social impacts of cosmetic products * Ethical sourcing and biodiversity * Renewable energy and waste management * Green formulations and ingredients * Green marketing issues and consumer behaviour * Green standards, certification schemes and indices in the cosmetics industry Industry experts share their experiences on how they are tackling the challenges of sustainability: from raw material procurements, manufacturing, business processes, to distribution and marketing to consumers. The book concludes with some future growth projections; what are some of the shortcomings in sustainability in the cosmetics industry and what can we expect to see in the future? Sustainability: How the Cosmetics Industry is Greening Up discusses business and technical issues in all areas of sustainable product development, from sourcing ingredients, to formulation, manufacture and packaging. Covering a diverse range of subjects, this book appeals to professionals in many key sectors of the cosmetics and personal care industry; cosmetic chemists, formulation scientists, R&D directors, policy makers, business and marketing executives. It is also of relevance to academic researchers working in cosmetic chemistry and sustainable process development.

A story of forbidden love that echoes across generations - from the prize-winning author of The Year of the Runaways. 'A gorgeous, gripping read' Kamila Shamsie 'A multi-generational masterpiece' Daily Mail * A Book of the Year for The Times, Guardian and Daily Telegraph * Mehar, a young bride in rural Punjab, is trying to discover the identity of her new husband. It is 1929, and she and her sisters-in-law - married to three brothers in a single ceremony - spend their days hard at work on the family farm, sequestered from contact with the men. When Mehar develops a theory as to which of them is hers, a passion is ignited that will put more than one life at risk. Spiralling around Mehar's story is that of a young man who in 1999 flees from England to the deserted sun-scorched farm. Can a summer spent learning of love and of his family's past give him the strength for the journey home? Readers love China Room ***** 'I didn't want it to end' ***** 'What. A. Book.' ***** 'Beautifully crafted...a story as old as time' ***** 'A novel of thwarted loves' Shortlisted for the 2022 Rathbones Folio Prize Longlisted for the 2021 Booker Prize Longlisted for the 2022 Walter Scott Prize Longlisted for the 2021 Ondaatje Prize 'Amazing storytelling...gripping and very moving' BBC Radio 4, Open Book 'I'm blown away by it' Tessa Hadley 'The stuff of miracles' Bryan Washington 'Moving...fresh and nourishing' The Times

'Genuine, poignant ...A moral work of real intelligence and power' John Burnside, The Times When Imtiaz Raina leaves England for the first time, to bury his father on his family's land near Lahore, he exchanges his uncertain life in Sheffield for a road that leads to the mountains of Kashmir and Afghanistan. Once back in Yorkshire, he writes through the night to his young wife Becka and baby daughter Noor, and tries to explain, in a story full of affection and yearning, what has happened to him and why he has a devastating new sense of home. 'What Sahota creates is not an exploration of the psyche of a suicide bomber, but an exploration of a man' Yorkshire Post 'Startling. This book successfully humanizes one of the great demons of contemporary society, and for that, Sunjeev Sahota should be given a high five off the Queen or something' Dazed and Confused, 'Book of the Month' 'Imtiaz's journey to Pakistan, and his sense of belonging, gives the novel much of its eloquence. Great literary promise' Independent 'Excruciatingly well-written' Guardian 'The book's great force lies in its voice: that of a young man straining to express instincts, fears and emotional conflicts, lending his writing a distinctive vibrancy' Observer 'An acute debut. What is most chilling, and most successful, is that it all seems so familiar, so close and so easy' Sunday Times

America is a 24/7 lifestyle. This makes sleep--especially disruptions in sleep--a pressing concern for many Americans. According to the National Sleep Foundation (NSF), approximately 40 million Americans suffer from chronic sleep disorders, and an estimated 20-30 million others experience sleep-related problems. Chronic sleep disorders may also lead to psychiatric disorders such as depression and schizophrenia. Moreover, neurological disorders such as seizures, strokes, Parkinson's, etc, and medical disorders such as asthma or arrhythmia, also affect the quality of sleep Americans receive.
Acute and Emergent Events in Sleep Disorders creates awareness for the management of disorders that occur during sleep. Chokroverty and Sahota bring greater awareness to the treatment of sleep disorders, as well as treatments of neurological, medical, and psychiatric disorders. The book has six different sections covers a wide range of topics dealing with how to treat and manage these events. For example, when to prescribe CPAP (Continuous Positive Airway Pressure) machines for sleep apnea patients' whose risks are doubled for stroke or death, as compared to those without the disorder. Another segment discusses treatment of Restless Legs Syndrome (RLS), a movement disorder which is amplified when trying to rest. Managing depression, which affects patients' sleep cycles, is analyzed as well as its relation to sleep-deprivation and insomnia. Considerations for sleep disorders in children, such as Sudden Infant Death Syndrome (SIDS) are also presented. This book serves an effective tool for neurologists, clinical neuroscientists, residents, and fellows.