Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

SOON TO BE A MAJOR MOTION PICTURE FROM 20TH CENTURY FOX Two reckless but lovable all-American bros make a strong case for maturing slowly through their outrageous yet enlightening misadventures. My brother and I are looking for wedding dates for our cousin's wedding. We've been told by the bride that bringing dates is "mandatory" so we "won't harass all of my friends all night" and "stay under control." Rather than ask some fringe women in our lives to go and face the inevitable `does this mean he wants to take it to the next level?!' questions, we'd rather bring complete strangers and just figure it out...We're both in our 20s, single, dashingly tall, Anglo-Saxon, respectfully athletic, love to party, completely house trained...love our mother, have seen Love Actually several times...raw, emotional, sensitive, but still bad boys....You should be attractive or our aunts will judge you, but not TOO attractive or one of our uncles might grope you. Dave and Mike Stangle thought nothing of it when they boozily decided to turn to the "activity partners" section of Craigslist to solicit dates to their cousin's wedding. The hilarious, out-of-this-world ad that they came up with-featuring a picture of the two brothers as centaurs-immediately went viral, eventually landing these Wayfarers-wearing, moped-riding, completely reckless but ultimately loveable bros in the annals of the "Internet famous." With the incredible comedic chemistry of Vince Vaughn and Owen Wilson in Wedding Crashers and the uncensored honesty of Tucker Max, Mike and Dave insist there's nothing wrong with just seeing where life takes you.

This remarkable text raises the analysis of data in health sciences and policy to new heights of refinement and applicability by introducing cutting-edge meta-analysis strategies while reviewing more commonly used techniques. Each chapter builds on sound principles, develops methodologies to solve statistical problems, and presents concrete applications used by experienced medical practitioners and health policymakers. Written by more than 30 celebrated international experts, Meta-Analysis in Medicine and Health Policy employs copious examples and pictorial presentations to teach and reinforce biostatistical techniques more effectively and poses numerous open questions of medical and health policy research.

Two reckless but lovable all-American bros make a strong case for maturing slowly through their outrageous yet enlightening misadventures across this great country of ours.
"My brother and I are looking for wedding dates for our cousin's wedding."
"We've been told by the bride that bringing dates is "mandatory" so we "won't harass all of my friends all night" and "stay under control." Rather than ask some fringe women in our lives to go and face the inevitable 'does this mean he want to take it to the next level? ' questions, we'd rather bring complete strangers and just figure it out..."
"We're both in our 20s, single, dashingly tall, Anglo-Saxon, respectfully athletic, love to party, completely house trained...love our mother, have seen "Love Actually" several times...raw, emotional, sensitive, but still bad boys....You should be attractive or our aunts will judge you, but not TOO attractive or one of our uncles might grope you."
Dave and Mike Stangle thought nothing of it when they boozily decided to turn to the "activity partners" section of Craigslist to solicit dates to their cousin's wedding. The hilarious, out-of-this-world ad that they came up with--featuring a picture of the two brothers as centaurs--immediately went viral, eventually landing these Wayfarers-wearing, moped-riding, completely reckless but ultimately loveable bros in the timeless realm of the Internet famous.
In "Mike and Dave Need Wedding Dates," the Stangle brothers bring their trademark, off-color humor to everything from their most embarrassing adolescent experiences (like getting beat up by a girl on their front lawn...in front of their dad), to the most outrageous predicaments (like tripping on mushrooms with their bulldog, Frank), to proper sexting etiquette, and finally to breaking up a midget bar fight (you have to shoo them away). With the incredible comedic chemistry of Vince Vaughn and Owen Wilson in "Wedding Crashers" and the uncensored honesty of Tucker Max, Mike and Dave rule firmly, yet kindly over their bro-dom, insisting there's nothing wrong with just seeing where life takes them.

This is a book about mathematical modelling. It focuses on the modelling of the preparation of materials. Materials are important, of course, in an economic sense: the "goods" of goods-and-services are made of materials. This provides a strong incentive to produce good materials and to improve existing materials. Mathematical modelling can help in this regard. Without a doubt, modelling a materials processing operation is not strictly necessary. Materials synthesis and fabrication processes certainly existed before the invention of mathematics and computers, and well before the combined use of mathematics and computers. Modelling can, however, be of assistance--if done properly--and if used properly. The mathematical modelling described in this book is, at its root, a rather formal, structured way of thinking about materials synthesis and fabrication processes. It requires looking at a process as a whole. It requires considering everything that is or might be important. It requires translating the details of a given physical process into one or more mathematical equations. It requires knowing how to simplify the equations without over-simplifying them.

This book offers a new perspective on the concept of modernity. Since its invention as a contrast to Antiquity or the Middle Ages, modernity has been tied to ideas of superiority, progress, and efficiency. As a counterpart to the Marxist "history of class struggle", "modernization theories" have transformed modernity into an almost teleological concept of historical development. These strong connotations obstruct a clear look at other forms of modernity. The contributions of the volume will show in a comparative perspective how modernity can also be understood and analyzed as multiple responses of societies and polities to organize themselves in facing ever more complex and integrated interactions at ever larger scales.

This work provides descriptions, explanations and examples of the Bayesian approach to statistics, demonstrating the utility of Bayesian methods for analyzing real-world problems in the health sciences. The work considers the individual components of Bayesian analysis.;College or university bookstores may order five or more copies at a special student price, available on request from Marcel Dekker, Inc.

Two Worlds of Drug Consumption in Late Modern Societies reports the findings of an empirical study of drug users in London, Amsterdam, Turin, Prague, Vienna and Warsaw, European cities representative of a wide range of drug problems and public policies. The innovative study reconceives the standard distinctions between 'hard-core' and 'recreational' drug users in terms of their social position. The authors argue that this is closely related to consumption patterns rather than drug choice, and reveals that 2 relatively homogenous drug worlds exist within each of the study sites. This leads to the development of diverging drug markets; a friendly market for the integrated consumer, and a highly commercialized one for the marginalized customer, where low quality goods are sold at a higher price. These findings have significant implications for academics and professionals working in health, psychology and urban studies.

This book presents the latest research into the application of information and communication technologies within the travel and tourism sectors. Readers will find insightful contributions on a wide range of topics, including digital marketing, social media and online travel reviews, mobile computing, augmented and virtual reality, gamification, recommender systems, electronic distribution, online education and learning, and the sharing economy. Particular attention is devoted to the actual and potential impact of big data, and the development and implementation of digital strategies, including digital marketing and the digital economy. In addition to the description of research advances and innovative concepts, a number of informative case studies are presented. The contents of the book are based on the 2018 ENTER eTourism conference, held in Joenkoeping, Sweden. The volume will appeal to all academics and practitioners with an interest in the most recent developments in eTourism.

This book presents state-of-the-art research into the application of information and communication technologies to travel and tourism. The range of topics covered is broad, encompassing digital marketing and social media, mobile computing and web design, semantic technologies and recommender systems, augmented and virtual reality, electronic distribution and online travel reviews, MOOC and eLearning, eGovernment, and the sharing economy. There is a particular focus on the development of digital strategies, the impact of big data, and the digital economy. In addition to the description of research advances and innovative ideas, readers will find a number of informative industrial case studies. The contents of the book are based on the 2017 ENTER eTourism conference, held in Rome. The volume will be of interest to all academics and practitioners who wish to keep abreast of the latest developments in eTourism.

This is a book about mathematical modelling. It focuses on the modelling of the preparation of materials. Materials are important, of course, in an economic sense: the "goods" of goods-and-services are made of materials. This provides a strong incentive to produce good materials and to improve existing materials. Mathematical modelling can help in this regard. Without a doubt, modelling a materials processing operation is not strictly necessary. Materials synthesis and fabrication processes certainly existed before the invention of mathematics and computers, and well before the combined use of mathematics and computers. Modelling can, however, be of assistance--if done properly--and if used properly. The mathematical modelling described in this book is, at its root, a rather formal, structured way of thinking about materials synthesis and fabrication processes. It requires looking at a process as a whole. It requires considering everything that is or might be important. It requires translating the details of a given physical process into one or more mathematical equations. It requires knowing how to simplify the equations without over-simplifying them.

"Rate Adaptive Cardiac Pacing" provides a comprehensive overview of this most advanced form of stimulating the heart by means of cardiac pacemakers that vary the pacing rate according to the needs of the patients. The heart rate is controlled by one or several sensors that detect various parameters such as respiration, blood temperature, oxygen saturation, intracardiac pressure, QT interval, stroke volume andbody activity. Besides describing the clinical and functional characteristics of these various sensors, the book also gives a clear understanding of hemodynamic aspects and in particular, all clinical issues of importance such as indications for rate adaptive pacing and selection of the appropriate patients for rate adaptive pacemakers, with many ECG samples. The book also covers new concepts in rate adaptive pacing such as single lead atrial synchronous pacing and the combination of various sensors, which are among the most recent developments in the field. With contributions from the most wellknown experts in the field from allover the world, this book is the first publication to cover all the hemodynamic, clinical and technical aspects of rate adaptive cardiac pacing.

This remarkable text raises the analysis of data in health sciences and policy to new heights of refinement and applicability by introducing cutting-edge meta-analysis strategies while reviewing more commonly used techniques. Each chapter builds on sound principles, develops methodologies to solve statistical problems, and presents concrete applications used by experienced medical practitioners and health policymakers. Written by more than 30 celebrated international experts, Meta-Analysis in Medicine and Health Policy employs copious examples and pictorial presentations to teach and reinforce biostatistical techniques more effectively and poses numerous open questions of medical and health policy research.

The material for this book first appeared in the magazine Personal Computer World, as a series of articles which ran from September 1979 to June 1980. It was designed to appeal to a new (in 1979) sort of reader the microcomputer enthusiast, both amateur and professional about whom two assumptions were made. The first was that the reader was someone who had already learned to program (probably in BASIC) and who wanted to create programs in as systematic and proficient a fashion as possible. The second was that the reader would not be adverse to an occasional glimpse of how the underlying machine played its part in executing these programs. As a result of these, no attempt was made to teach the "problem-solving" aspects of programming (although the Top-Down philosophy for program design formed a key feature) and no apology was made for the repeated references to the way in which a Pascal compiler "viewed" some particular code fragment. In preparing this material for publication as a single volume, there has been little deviation from this policy. Nevertheless, it should be remarked that the first five chapters contain all the material one would need to cover in an initial course in programming (up to the level of most BASIC's) while the second half of the book tackles some of the more sophisticated techniques available to the Pascal programmer.

In the aftermath of the Second World War, Berliners grappled with how to rebuild their devastated city. In East Berlin, where the historic core of the city lay, decisions made by the socialist leadership about what should be restored, reconstructed, or entirely reimagined would have a tremendous and lasting impact on the urban landscape. Risen from Ruins examines the cultural politics of the rebuilding of East Berlin from the end of World War II until the construction of the Berlin Wall, combining political analysis with spatial and architectural history to examine how the political agenda of East German elites and the ruling Socialist Unity Party (SED) played out in the built environment. Following the destruction of World War II, the center of Berlin could have been completely restored and preserved, or razed in favor of a sanitized, modern city. The reality fell somewhere in between, as decision makers balanced historic preservation against the opportunity to model the Socialist future and reject the example of the Nazi dictatorship through architecture and urban design. Paul Stangl's analysis expands our understanding of urban planning, historic preservation, modernism, and Socialist Realism in East Berlin, shedding light on how the contemporary shape of the city was influenced by ideology and politics.

Was geschieht mit den verzehrten Lebensmitteln im Koerper? Welche Nahrstoffe brauchen wir in welchem Lebensalter, und kann Nahrung auch schadlich sein? Das Lehrbuch gibt einen umfassenden UEberblick uber die ernahrungsphysiologischen Grundlagen, die zum erfolgreichen Bestehen eines ernahrungswissenschaftlichen Studiums erforderlich sind. Kurze einfuhrende Beispiele eroeffnen die Kapitel und werfen so wichtige Fragen auf, die im weiteren Verlauf aufgegriffen werden. Zahlreiche Abbildungen und Kurzzusammenfassungen erleichtern das Lernen und die Prufungsvorbereitung. Das Lehrbuch beschreibt auf anschauliche Weise, wie Nahrstoffe aufgenommen werden, welche Funktionen sie im Koerper haben und welcher Regulation sie unterliegen. Weitere Kapitel befassen sich mit den verschiedenen Methoden der Ernahrungserhebung und den besonderen Nahrstoffbedurfnissen von Menschen im Laufe ihres Lebenszyklus sowie mit der Ernahrungstoxikologie. Das Lehrbuch greift in einzigartiger Weise auch die vorgeburtliche Ernahrung auf und behandelt, wie wir Nahrungsmittel schmecken und riechen, wie die Gefuhle von Hunger und Sattigung entstehen und welche Inhaltsstoffe von Lebensmitteln uns schaden.

Zum 70. Geburtstag unseres verehrten Lehrers freuen wir uns, uber einen Teil seines Lebenswerkes berichten zu koennen, und wollen damit unserem Dank fur alles, was wir in langjahriger Arbeit an seiner Klinik lernen durften, Ausdruck geben. Schon wahrend seiner Assistentenzeit an der Klinik E i s e l s b e wandte r g D e n k sein Interesse der Thoraxchirurgie in besonderem Masse zu, die er seither in OEsterreich zum Erfolg fuhrte. Zahlreiche seiner Schuler, die er im Laufe seiner jahrzehntelangen Tatigkeit als klinischer Lehrer herangebildet hat, sind heute als Thoraxchirurgen in leitender Stellung tatig. Seit Jahren beschaftigte sich Denk besonders mit den Problemen der Lungen resektion und konnte schon 1938 die erste einzeitige Lobektomie wegen Bronchiektasien erfolgreich ausfuhren. Durch die enorm erschwerten Arbeitsbedingungen 'in den folgen den Kriegsjahren waren die Fortschritte auf dem Gebiete der Lungenresektionen weit gehend gehemmt, so dass nur vereinzelte derartige Operationen durchgefuhrt werden konnten. Als nach Kriegsende die grossen Erfolge des \Vestens auf thoraxchirurgischem Gebiet bekannt wurden, war es D e n k, der durch Einsatz seiner ganzen Persoenlichkeit diesen Vorsprung wieder einholte. Es ist daher nicht verwunderlich, dass sich in den letzten Jahren ein sehr grosses thoraxchirurgisches Krankengut an seiner Klinik konzen trierte. Schon Anfang 194 7 konnte D e n k, noch mit unzulanglichen technischen Hilfs mitteln, die erste erfolgreiche Pneumonektomie wegen Bronchuscarcinom durchfuhren. In den folgenden Jahren nahm der Zustrom an Bronchuscarcinomkranken immer weiter zu, so dass wir derzeit uber mehr als 1200 derartige Falle verfugen.

Die Herzschrittmachertherapie ziihlt zweifelsohne zu den groBen Fortschritten medizini- scher Erkenntnisse der letzten dreiBig Jahre. Menschen, deren Leben bis auf einige wenige Jahre begrenzt war, bekamen es neu geschenkt. Ihre Lebenserwartung konnte nachhaltig verliingert, ihre Lebensqualitiit entscheidend verbessert werden. Die Schritt- macherentwieklung ist aber nieht stehengeblieben. Gerade zur Verbesserung der Lebens- qualitiit konnten in der Entwicklung der letzten Jahre groBe Fortschritte erzielt werden. Das urspriingliche Therapiekonzept war die Verhinderung von Adams-Stokes-Anfiillen, zuniichst beim kompletten AV-Block, aber schon sehr rasch bei allen bradykarden Rhythmusstorungen. Einen wesentliehen Fortschritt stellte hierzu die Einflihrung der Demand-Funktion dar, die eben nur im Bedarfsfall, d. h. beim plotzlichen rhythmogenen Ausfall der Herztiitigkeit, einsetzte, das asystolische Intervall uberbruckte und damit den Adams-Stokes-Anfall verhinderte, ohne sonst die Herztiitigkeit zu storen. Das niich- ste Therapiekonzept betraf die Verbesserung der Hiimodynamik mit dem Ziel, durchAn- hebung der zu langsamen Ruhefrequenz eine Steigerung des Herzminutenvolumens her- beizuflihren. Sehr rasch muBte man jedoch erkennen, daB gerade bei der Hauptgruppe dieser Patienten, d. h. Patienten mit Sinusbradykardie, der gewtinschte Effekt in vielen Fallen ausblieb. Trotz Frequenzanhebung ging es einem Teil dieser Patienten eher schlechter, in manchen Fiillen kam es sogar zu Blutdruckabfall und kollapsiihnlichen Zu- stiinden. Der Begriff "Schrittmachersyndrom" kam auf. Die Losung flir solche Fiille war die Einflihrung der Vorhofstimulation (AAI), die wiederum die Entwieklung geeigneter Vorhofelektroden und Implantationstechniken zur Voraussetzung hatte. Damit lieB sich die Herzfrequenz anheben bei Erhalt der AV-Uberleitung, d. h. physiologischer AV-Syn- chronisation (physiologischer Schrittmacher).

Die Bevoelkerungszahlen sind eine wichtige Grundlage fur das Verstandnis historischer Ablaufe in der Antike. Zahlen lassen sich am leichtesten miteinander vergleichen und sind quantitativer Ausdruck des Wirtschafts- und Militarpotentials einer politisch-geographischen Einheit. In dieser Arbeit wurde versucht, die verschiedenen Methoden der Schatzung einer solchen Einheit zu kombinieren und zu bewerten, basierend auf antiken literarischen und historischen Quellen, auf archaologischen Befunden und Modellen der Demographie, Wirtschaft, OEkologie und Technologie. Als besonders geeignet erwies sich die Kombination aus Heeresstarken und oekologischem Potential (Agrarflachen).

Most of us are far from perfect in virtue. But even those who come far closer to perfect virtue than most of us—people like Mother Theresa, Martin Luther King, Jr., or Gandhi—nonetheless fall short of possessing it: not even moral saints and heroes are perfectly virtuous. Faced with this fact, moral philosophers can respond in two different ways: they might insist that the only real virtue is perfect virtue, and the only right actions are perfectly virtuous ones. Any failure to meet the exacting standards of perfect virtue will amount to vice, and any less than perfectly virtuous actions will be wrong. Or, if they reject such a rigorist picture, they can instead affirm that there are actions that are truly good and right even if they fall short of perfection. In this book, philosopher Rebecca Stangl urges the attractions of a virtue ethics committed to the second option, and in doing so, pushes forward two major innovations. First, she constructs and defends Neo-Aristotelian accounts of supererogation and suberogation, arguing such accounts are fully consistent with such traditional Aristotelian claims as the doctrine of the mean, the necessity of virtue, and the role of the phronimos in our moral epistemology. And further, far from encouraging a kind of complacency, she shows the recognition that there can be genuine goodness short of perfection is precisely what opens up theoretical space for appreciating the goodness of striving towards ideal virtue. The second major innovation of the book is its argument that self-improvement itself can be morally excellent, and the disposition to seek and engage in it, where appropriate, is itself virtuous. She terms this a virtue of self-cultivation, and the book defends and develops a rigorous account of its nature and value.

In den letzten Jahren zeichnet sich immer deutlicher ab, dass es eine Reihe von geschlechtsspezifischen Unterschieden hinsichtlich Entstehung, Verlauf, Klinik und Prognose von Herzerkrankungen gibt. Diese Unterschiede rasch zu erkennen und eine ad quate Versorgung einzuleiten, ist besonders bei akuten Notf llen und in der Intensivmedizin von gro er Bedeutung.

In der Spezialsituation der herzkranken Frau in der Schwangerschaft ist eine sehr enge interdisziplin re Zusammenarbeit zwischen Intensivmedizinern, Kardiologen, Gyn kologen und An sthesisten insbesondere w hrend der peripartalen Phase unabdingbare Voraussetzung f r eine optimale Betreuung der Risikopatientinnen.

Dieser Sammelband mit Artikeln der Zeitschrift "Intensivmedizin und Notfallmedizin" aus den Jahren 2003 und 2004 gibt eine bersicht ber die klinisch relevanten Problemkomplexe bei der Betreuung von herzkrankenPatientinnen in solchen Intensiv- und Notfallsituationen.