A BOOK OF THE YEAR FOR THE GUARDIAN: 'DEEPLY PLEASURABLE' A BOOK OF THE YEAR FOR THE SPECTATOR: 'WHAT A JOY' 'Magnificent' Guardian 'A towering achivement' Financial Times 'Inventive, bold, unexpected' Sunday Times 'Everything that makes the novel worthwhile and engaging is here: warmth, wit, intelligence, love, death, high seriousness, low comedy, philosophy, subtle personal relationships and the complex interior life of human beings' Guardian 'Not since William Boyd's Any Human Heart has a novel captured the feast and famine nature of a single life with such invention and tenderness' Financial Times 'There is a pleasing sense of having grappled with the real stuff of life: loss, grief, love, desire, pain, uncertainty, confusion, joy, despair - all while having fun' The Sunday Times 'Instantly immersive, playfully inventive, effortlessly wise' Observer 'Masterly: a cabinet of curiosities and delights, packed with small wonders' Ian McEwan 'A real masterpiece. A funny, touching, profound book that made me cry like a little girl on the last page' Leila Slimani 'A remarkable accomplishment, a true gift to the world' Michael Cunningham 'Ardent, gripping, and inventive to the core' Jhumpa Lahiri Marco Carrera is 'the hummingbird,' a man with the almost supernatural ability to stay still as the world around him continues to change. As he navigates the challenges of life - confronting the death of his sister and the absence of his brother; taking care of his parents as they approach the end of their lives; raising his granddaughter when her mother, Marco's own child, can no longer be there for her; coming to terms with his love for the enigmatic Luisa - Marco Carrera comes to represent the quiet heroism that pervades so much of our everyday existence. A thrilling novel about the need to look to the future with hope and live with intensity to the very end. THE NO. 1 INTERNATIONAL BESTSELLER Over 300,000 copies sold Soon to be a major motion picture Winner of the Premio Strega Winner of the Prix du Livre Etranger Book of the Year for the Corriere della Sera

Humans have long neglected to fully consider the impact of their behaviour on the environment. From excessive consumption of fossil fuels and natural resources to pollution, waste disposal, and, in more recent years, climate change, most people and institutions lack a clear understanding of the environmental consequences of their actions. The new field of behavioural environmental economics seeks to address this by applying the framework of behavioural economics to environmental issues, thereby rationalizing unexplained puzzles and providing a more realistic account of individual behaviour. This book provides a complete and rigorous overview of environmental topics that may be addressed and, in many instances, better understood by integrating a behavioural approach. This volume features state-of-the-art research on this topic by influential scholars in behavioural and environmental economics, focussing on the effects of psychological, social and cognitive factors on the decision-making process. It presents research performed using different methods and data collection mechanisms (e.g. laboratory experiments, field experiments, natural experiments, online surveys) on a variety of environmental topics (e.g. sustainability, natural resources). This book is a comprehensive and innovative tool for researchers and students interested in the behavioural economics of the environment and in the design of policy interventions aimed at reducing the human impact on the environment.

Humans have long neglected to fully consider the impact of their behaviour on the environment. From excessive consumption of fossil fuels and natural resources to pollution, waste disposal, and, in more recent years, climate change, most people and institutions lack a clear understanding of the environmental consequences of their actions. The new field of behavioural environmental economics seeks to address this by applying the framework of behavioural economics to environmental issues, thereby rationalizing unexplained puzzles and providing a more realistic account of individual behaviour. This book provides a complete and rigorous overview of environmental topics that may be addressed and, in many instances, better understood by integrating a behavioural approach. This volume features state-of-the-art research on this topic by influential scholars in behavioural and environmental economics, focussing on the effects of psychological, social and cognitive factors on the decision-making process. It presents research performed using different methods and data collection mechanisms (e.g. laboratory experiments, field experiments, natural experiments, online surveys) on a variety of environmental topics (e.g. sustainability, natural resources). This book is a comprehensive and innovative tool for researchers and students interested in the behavioural economics of the environment and in the design of policy interventions aimed at reducing the human impact on the environment.

This timely comparative study assesses the role of medical doctors in reforming publicly-funded health services in England and Canada. Respected authors from health and legal backgrounds from both sides of the Atlantic consider how the high status of the profession uniquely influences reforms. With summaries of developments in models of care and the participation of doctors since the inception of publicly-funded healthcare systems, they ask whether professionals might be considered allies or enemies of policymakers. With insights for future health policy and research, the book is an important contribution to debates about the complex relationship between doctors and the systems in which they practice.

This book deep dives into emerging consumer trends in the food and beverage industry in Italy, particularly in light of the COVID-19 crisis, and explores how firms have evolved to meet consumer needs and succeed in this challenging context. Through a series of case studies, the authors explore the food and beverage industry's defining characteristics and how each particular sector has become so important to the Italian economy. Drawing on cases that feature small, medium and large enterprises, the authors reveal how firms have adapted their business strategies to meet new customer demands and market trends, highlighting the winning characteristics of the ever-evolving 'Made in Italy' brand, concluding with a recommended strategy of best practices for future implementation. Providing examples that can be studied, applied and analyzed by researchers, students, and practitioners, this unique book offers a detailed understanding of the different innovations and adaptations that companies in the food and beverage sector have put in place in response to ever evolving markets and trends, and how innovation becomes the key to success.

A sophisticated psychological novel from one of Europe's most exciting writers. '"Are you an unhappy man?" That's what the journalist said to me. It was her last question.' Gianni Orzan has no reason to feel unhappy. He has just been awarded a prize for his children's writing and a cheque for fifteen million lire. He is blissfully married to Anna and is a doting father to an eight-year-old son, Franceschino. He loves film and is an avid chess player. He is a man in complete control of his life. But when Gianni leaves the award ceremony, a chain of events are set in motion that will shatter this perfect life. In an uncharacteristically rash moment he accepts a ride from an unlicensed cab driver. As soon as the car pulls off he feels unnerved. At the first set of lights the driver turns, smiles at Gianni, a pistol butt poking from his belt, and says - 'So, Franceschino has finally learned to ride his bicycle...'. Gianni bolts from the cab. But it's too late; in this briefest of moments the serenity of Gianni Orzan's life has been destroyed. Later, after he has sent his wife and son to stay with family, the same cab driver appears at his door and introduces himself as Gianni's father's oldest friend. He certainly talks accurately about Gianni's father, who died less than a fortnight ago. In fact, he seems to know much more about Gianni's respectable, pious father than Gianni ever did, or perhaps ever wants to. Reminiscent of Ian McEwan's 'Enduring Love', 'The Force of the Past' is a breathtakingly clever and entirely gripping story of how a calm, ordinary life can rapidly unravel.

The book tells the story of a life from birth through childhood, independence, isolation, confrontation, desolation, a journey through deserts and across rivers and thunderstorms, in search for one's place in the world. The characters carrying the story forward with each image are different, but the story is one. The story of life, of dreams, of struggle, of resilience, of making it through the hardness life throws on all of us. The book features images primarily from East Africa, the wide open spaces of the Mara-Serengeti ecosystem and Amboseli. Also included are images from the Namib desert and the stunning enchanted forest of Mana Pools, in Zimbabwe.

Microwave Chemistry has changed the way to work in chemical laboratories and is an established state-of-the-art technology to accelarate and enhance chemical processes. This book not only gives an overview of the technology, its historical development and theoretical background, but also presents its exceptionally broad spectrum of applications. Microwave Chemistry enables graduate students and scientist to learn and apply its methods successfully.

A unique keepsake of a very special time in a woman's life: her pregnancy. The nine months of pregnancy are a period of expectation, surprises, novelties, and busy preparation for the new baby. This contemporary, colorful journal commemorates that amazing time, giving the mom-to-be space to record her thoughts and emotions, and gather photographs and other souvenirs. It has pages to hold the first ultrasound; record the father's reactions; list favorite names; create a gift registry; and so much more. Moms will treasure this forever.

Blood transfusion is considered a life-saving therapy since ancient times, but, at the same time, a high-risk procedure. Nowadays the common perception is that infection is the greatest risk, even if the blood has never been safer from this point of view. Currently, the residual risk of transfusion must be related mainly to immunological mechanisms underlying to AB0 and minor blood systems, to compatibility of blood transfused and to development of irregular antibodies in transfused patients. "Transfusion Medicine and Patient Safety" aims to provide the basic of immunohematology to readers and to analyze the transfusional process highlighting the most critical points, thus more exposed to errors. Screening on blood and blood components for infectious diseases along with the surveillance action on emerging viruses results in the drastic reduction of post-transfusion infection, together with the potential to further increase the level of security from infection through the inactivation of blood components. The text also describes the major diagnostic systems and organizational models that modern technology provides us with a correct immunohematological diagnosis and an appropriate trasfusional therapy.

This multidisciplinary work explores ways of making environmental policy decisions in managing public goods and natural parks with the goal of maximizing economic benefits to society. The contributors to the volume seek the best strategies for improving the environmental sustainability and quality of a public resource by showing how to develop quantitative information about the natural area and how it interacts with the economy. Such an analysis can be used to define policies that encourage interactions among institutions, local economic agents and park users. At the same time, it provides a measure to account for the implications of those policies on the local economy.A public resource, such as a natural park, has many different functions - the production of marketed goods, ecosystem protection and tourism - and its management requires the knowledge of the physical, biological and ecological characteristics of the functions supplied by the resource, as well as the value of each function and the public resource as a whole. To ensure the implementation of the optimal practice, the contributors adopt a participative approach to establish a credible social contract between the area's public manager and its consumers. Balancing the interests of residents, visitors and local businesses, and coupling the development of both the natural potential of the area and the local economy, are necessary steps for the best strategy to be adopted. Economists and agricultural-environmental economists, forest and resource planners interested in practical guidance, and professors who teach environmental economics or forest planning courses will all find this collection invaluable and instructive.

The problem of digestive tract tumors presents multifaceted aspects which involve epidemiology, pathogenesis, histopathology, surgery and adjuvant multidisciplinary mo dality. Time trends in cancer mortality vary in the individual cancers. Mortality from stomach cancer shows a decreasing tendency in most countries, although Japan still has the highest incidence in the world. Intestinal other than rectum and pancreatic cancers have shown an increase in most countries, while mortality due to liver cell and gallbladder cancer vary greatly by locality. Since most cancers are considered to be related to en vironmental and lifestyle exposures, such as diet, smoking or excessive drinking, there is hope that action on these factors may serve to substantially reduce occurrence of the disease. Recent progress in early diagnosis has made it feasible to detect small and minute cancers, and these have proven possible to cure with relatively favorable results. The most important advancement has come from a multidisciplinary approach to cancer treatment, utilizing a balanced application of surgery, radiation therapy and chemo therapy. A considerable increase in the five-year survival rate has been realized in stomach cancer. While progress is being made in the practical treatment of this disease, it remains far better to prevent than to cure. For the first time immunization offers a unique op portunity to prevent liver cell cancer."

Metastases determine malignancy. The main attention so far has been focused upon organ metastases. The molecular mechanisms thereof, while far from being totally elucidated, are increasingly well understood. Modern diagnostic tools now enable detection and precise localization of small lesions. In contrast, our knowl edge and diagnostic capabilities regarding metastatic spread to the'lymphatic system are rather limited. However, there have re cently been a number of interesting advances. It is the aim of this volume to submit these developments to detailed analysis. The therapeutic relevance of enhanced sensitivity in detection of lymph node metastases has to be considered in the light of in creased morbidity versus eventual prognostic improvements by modification of therapy. An interesting concept which might im prove diagnostic accuracy while reducing operative morbidity is the "sentinel node" technique. Surgical standards are lacking, however, and many fundamental questions pertaining to precise lymphatic mapping remain unanswered. Whether the sentinel node concept is of general relevance or whether it is applicable in only a few organs remains to be determined. This book offers intensive discussion of the concept from methodological and tu mor biological viewpoints. World-renowned experts with long term involvement in related basic and clinical research provide the reader with a broad survey of actual knowledge together with a critical appraisal of recent and future developments. We sincerely hope this book succeeds in providing an outlook as a reference for all clinicians on future prospects and serving and researchers in this extremely important field.

Grassland farming in Europe was already established during the settlement of the rst farmers together with their domesticated animals after the last ice age. Since then, grassland provides the forage basis to feed ruminant animals for the p- duction of meat and milk. Depending on the ecological conditions and intensity of usage, various plant communities with different species developed, displaying a rich biodiversity. With the introduction of improved crop rotations at the end of the 16th century, grasses and legumes were also grown to an important extent as forage crops on arable land. In the last decades the importance of amenity grasses increased markedly, due to the demand of the society for new usages like landscape protection. Around 1900 interested farmers and academics identi ed the need for gra- land improvement through systematic selection and seed production. This marks the beginning of breeding and research in companies but also at universities and specialized research institutes. Plant collection started with many of the species that are still of importance today. The collected materials were grouped according to the intended use and some type of phenotypic selection was applied. Seed mul- plication of such populations was performed in pure stands and the harvested seed was marketed. Although the vegetative biomass and its quality are of utmost imp- tance in forage crop breeding, it is the seed yield potential which determines the commercial success of a new variety.

For doctors and students who wish to learn ultrasonography concisely yet comprehensively. The authors present the subject both systematically and practically, and with the facility of quick reference in mind, making generous use of flow-charts, tables and teaching-points. All general aspects of diagnostic ultrasound are covered, concentrating on those disorders encountered in the daily routine of scanning, but also referring to rarer conditions which need to be considered in differential diagnosis.

Grassland farming in Europe was already established during the settlement of the rst farmers together with their domesticated animals after the last ice age. Since then, grassland provides the forage basis to feed ruminant animals for the p- duction of meat and milk. Depending on the ecological conditions and intensity of usage, various plant communities with different species developed, displaying a rich biodiversity. With the introduction of improved crop rotations at the end of the 16th century, grasses and legumes were also grown to an important extent as forage crops on arable land. In the last decades the importance of amenity grasses increased markedly, due to the demand of the society for new usages like landscape protection. Around 1900 interested farmers and academics identi ed the need for gra- land improvement through systematic selection and seed production. This marks the beginning of breeding and research in companies but also at universities and specialized research institutes. Plant collection started with many of the species that are still of importance today. The collected materials were grouped according to the intended use and some type of phenotypic selection was applied. Seed mul- plication of such populations was performed in pure stands and the harvested seed was marketed. Although the vegetative biomass and its quality are of utmost imp- tance in forage crop breeding, it is the seed yield potential which determines the commercial success of a new variety.

The "Europe against Cancer" programme has, from its inception, emphasised the key role which general practitioners must play in the actions necessary to achieve its aim of reduc ing the incidence and the mortality from cancer in the European Community. General practitioners, because of their day-to-day direct and continuing contact with patients, playa role not only in primary prevention and education of patients, but also in motivating their patients to accept secondary prevention and screening, some of it carried out by general practitioners themselves. These preventive activities are in addition to their traditional role in the care and management of patients with cancer at home, and increas ingly, their role in active treatment. In view of the importance of the general practitioner in the "Europe against Cancer" pro gramme, the European Commission, with a view to providing general practitioners with up-tO-date useful information, has sponsored the production of this series of publications on organ based cancers, especially written for general practitioners. MICHEL RICHONNIER Coordinator of the" Europe against Cancer" programme, Commission ofthe European Communities, Brussels Preface The present textbook is the second in the series published by the Commission of the Euro pean Communities within the context of the "Europe Against Cancer" Programme. After lung cancer, it was felt that priority should be given to breast cancer, the most frequent neoplastic disease among European women.

It is a very special honour for me to be able to present this handbook of medical oncology, which under diverse headings and origins covers such a vast spectrum of experience. I be lieve the reader will be struck in particular by the impressive volume of information available, especially with regard to childhood tumours, which represent, today, an immense "lab oratory of hope". It is in this very field that we oncologists have been able to obtain the most consoling results in recent years. I feel sure that all those who read these chapters will find that their oncological competence is enriched and also in a certain sense that their wish to contribute to progress in can cer research and treatment has been renewed. In conclusion, my most heartfelt congratulations go to the authors for the excellent job they have done, as well as my ad miration for having been able to concentrate so much pre cious and innovative information into so little space. Umberto Veronesi Preface Since 1976, the VICC has been holding chemotherapy courses in all parts of the world, excluding North America and Australia. The Manual of Cancer Chemotherapy, origi nally devised as a didactic tool to be used by course partici pants, expanded itself in the successive editions to a compre hensive, although schematic, textbook of medical oncology.

In this book the editors and authors provide a comprehensive overview on basic research and clinical aspects of hereditary breast and gastric tumors. In particular, this updated editorial work aims to suggest guidelines for the clinical management of patients with hereditary diffuse gastric and lobular breast cancer. Special attention is given to E-cadherin (CDH1 gene) germline mutations, genetic screening approaches, the underlying molecular mechanisms and pathological and microscopic features. In addition, the book aims to define clinical criteria for genetic screening, and highlights current surgical treatment and clinical approaches for asymptomatic mutation carriers. Other inherited predispositions involving gastric and breast carcinoma are discussed as well. Divided into eight sections, the book starts by providing an epidemiological overview of gastric and breast cancers, followed by a section dealing with new descriptions of genetic pathways in hereditary cancer predispositions. The third section focuses on pathological features of the diseases, in an effort to bridge the gap between discovery and cancer therapy development. Subsequent sections of the book are dedicated to endoscopy and breast imaging, as well as risk-reducing surgeries to curb the risk of developing cancer. The sixth section focuses on the generation of ideas for the identification of targets and novel treatment strategies. Finally, in the seventh section the authors share the story of two patients and their experiences with the diagnosis and treatment of hereditary cancer. This multidisciplinary book brings together multiple disciplines in science and technology; specifically, medicine, surgery and biology. The majority of authors are members of the International Gastric Cancer Linkage Consortium (IGCLC) and of the European Cancer Prevention Organization (EJCPO), with relevant experience in this context. Offering in-depth insights into hereditary cancers, this book represents essential reading for students, researchers, and specialists who want to extend their knowledge on hereditary gastric and breast cancers.   

The deep understanding of the forces that affect the valuation, risk and return of fixed income securities and their derivatives has never been so important. As the world of fixed income securities becomes more complex, anybody who studies fixed income securities must be exposed more directly to this complexity. This book provides a thorough discussion of these complex securities, the forces affecting their prices, their risks, and of the appropriate risk management practices. "Fixed Income Securities," however, provides a methodology, and not a shopping list. It provides instead examples and methodologies that can be applied quite universally, once the basic concepts have been understood.

A BOOK OF THE YEAR FOR THE GUARDIAN: 'DEEPLY PLEASURABLE' A BOOK OF THE YEAR FOR THE SPECTATOR: 'WHAT A JOY' 'Magnificent' Guardian 'A towering achivement' Financial Times 'Inventive, bold, unexpected' Sunday Times 'Everything that makes the novel worthwhile and engaging is here: warmth, wit, intelligence, love, death, high seriousness, low comedy, philosophy, subtle personal relationships and the complex interior life of human beings' Guardian 'Not since William Boyd's Any Human Heart has a novel captured the feast and famine nature of a single life with such invention and tenderness' Financial Times 'There is a pleasing sense of having grappled with the real stuff of life: loss, grief, love, desire, pain, uncertainty, confusion, joy, despair - all while having fun' The Sunday Times 'Instantly immersive, playfully inventive, effortlessly wise' Observer 'Masterly: a cabinet of curiosities and delights, packed with small wonders' Ian McEwan 'A real masterpiece. A funny, touching, profound book that made me cry like a little girl on the last page' Leila Slimani 'A remarkable accomplishment, a true gift to the world' Michael Cunningham 'Ardent, gripping, and inventive to the core' Jhumpa Lahiri Marco Carrera is 'the hummingbird,' a man with the almost supernatural ability to stay still as the world around him continues to change. As he navigates the challenges of life - confronting the death of his sister and the absence of his brother; taking care of his parents as they approach the end of their lives; raising his granddaughter when her mother, Marco's own child, can no longer be there for her; coming to terms with his love for the enigmatic Luisa - Marco Carrera comes to represent the quiet heroism that pervades so much of our everyday existence. A thrilling novel about the need to look to the future with hope and live with intensity to the very end. THE NO. 1 INTERNATIONAL BESTSELLER Over 300,000 copies sold Soon to be a major motion picture Winner of the Premio Strega Winner of the Prix du Livre Etranger Book of the Year for the Corriere della Sera

A comprehensive guide to the current theories and methodologies intrinsic to fixed-income securities Written by well-known experts from a cross section of academia and finance, Handbook of Fixed-Income Securities features a compilation of the most up-to-date fixed-income securities techniques and methods. The book presents crucial topics of fixed income in an accessible and logical format. Emphasizing empirical research and real-life applications, the book explores a wide range of topics from the risk and return of fixed-income investments, to the impact of monetary policy on interest rates, to the post-crisis new regulatory landscape. Well organized to cover critical topics in fixed income, Handbook of Fixed-Income Securities is divided into eight main sections that feature: An introduction to fixed-income markets such as Treasury bonds, inflation-protected securities, money markets, mortgage-backed securities, and the basic analytics that characterize them Monetary policy and fixed-income markets, which highlight the recent empirical evidence on the central banks influence on interest rates, including the recent quantitative easing experiments Interest rate risk measurement and management with a special focus on the most recent techniques and methodologies for asset-liability management under regulatory constraints The predictability of bond returns with a critical discussion of the empirical evidence on time-varying bond risk premia, both in the United States and abroad, and their sources, such as liquidity and volatility Advanced topics, with a focus on the most recent research on term structure models and econometrics, the dynamics of bond illiquidity, and the puzzling dynamics of stocks and bonds Derivatives markets, including a detailed discussion of the new regulatory landscape after the financial crisis and an introduction to no-arbitrage derivatives pricing Further topics on derivatives pricing that cover modern valuation techniques, such as Monte Carlo simulations, volatility surfaces, and no-arbitrage pricing with regulatory constraints Corporate and sovereign bonds with a detailed discussion of the tools required to analyze default risk, the relevant empirical evidence, and a special focus on the recent sovereign crises A complete reference for practitioners in the fields of finance, business, applied statistics, econometrics, and engineering, Handbook of Fixed-Income Securities is also a useful supplementary textbook for graduate and MBA-level courses on fixed-income securities, risk management, volatility, bonds, derivatives, and financial markets. Pietro Veronesi, PhD, is Roman Family Professor of Finance at the University of Chicago Booth School of Business, where he teaches Masters and PhD-level courses in fixed income, risk management, and asset pricing. Published in leading academic journals and honored by numerous awards, his research focuses on stock and bond valuation, return predictability, bubbles and crashes, and the relation between asset prices and government policies.

Worldwide investigations on mesenchymal stromal/stem cells (MSC) have highlighted their regenerative potentials. Subsequent ex vivo & in vivo studies, with or without biomaterial combination, have explored MSC efficiency to repair damaged tissues and organs. This book investigates some of key factors on MSC biology & performance, such as the cell transportation procedures and the vasculogenesis after transplantation. One of the prerequisites for MSC introduction into clinic is their manipulation under good manufacturing practice (GMP) facilities that are often far from the operating theatre. Appropriate cell shipment conditions are poorly defined, therefore in this book we describe the impact of transportation on functional outcome focusing on bone regeneration. We then focused on an innovative approach of adipose tissue regeneration that reduced necrosis and significantly increased vasculogenesis compared with common surgical procedure for adipose tissue reconstruction based on autologous fat transfer. These data may be useful for anyone who studies MSC looking for their introduction into regenerative medicine approaches based on both their differentiation and secretory potentials