Investing in the future of Hopewell archae- adetailedagendaofpressingempiricalissues ology is the spirit in which this book has andintriguinginterpretivequestionsthatremain beenwrittenandisitssubstance. Ourpassion to be addressed in the attempt to understand to do so derives from our admiration of Hopewellpeoples. Hopewell peoples, themselves, and all they The first half of the book provides a achieved. Hopewell peoples of the Scioto synthesisandexpansionofcurrentknowledge valley and their neighbors were remarkable about the anthropology of Scioto Hopewell by any measure. Their graceful and powerful peoples: their natural and symbolically int- artwork, monumentalearthenarchitecture, and preted environments, subsistence, settlement knowledge of geometry and astronomy; their andmobilitypatterns, communityorganization social finesse in choreographing ritual perfor- at several scales, social-political-ritual orga- manceswithmanyhundredsofpersons, local zation, and world view, and the history of and foreign; the long-lasting intercommunity changes of each of these over time. Coming peacetheyachievedthroughtherichandcross- to an understanding of how Scioto Hopewell cuttingsocialandritualtiestheywove;andtheir social-ceremonial life abruptly began and extraordinary sensitivity to and relations with abruptlyended, neitherofwhichweretriggered theanimalpersonsandspiritbeingswithwhom proximally by subsistence or demographic they cohabited-each humble the Western change, isoneofthefruitsbornfromattempting mind. Forus, itseemsonlyrightandworthwhile thebroadsynthesis. Theethnohistorypresented thatanempiricalandconceptualpathbecleared hereismadetangiblewithover195photographs wherebyfuturearchaeologicalworkmighthelp of artistic renderings that Scioto Hopewell Hopewellpeoplestospeakbetterforthemselves peoples made of themselves, of artifacts that oftheirlives, accomplishments, concerns, and marked their social roles and were used in disappointments. theirceremonies, andofviewsoftheirsacred This book shares with you the empirical landscape. toolsandabroadvisionforexploringtheways The reconstruction of Scioto Hopewell of Scioto Hopewell and other Ohio Hopewell life presented in this book is an integratio

Whether you can admit it to yourself or not, you are creative.
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In 1892, Lord Frederick Arthur Stanley donated the Dominion Hockey Challenge Cup - later known as the Stanley Cup - to crown the first Canadian hockey champions. Canada's Holy Grail documents Lord Stanley's personal politics, his desire to affect Canadian nationality and unity, and the larger transformations in Anglo-liberal political thought at the time. This book posits that the Stanley Cup fit directly within Anglo-American traditions of using sport to promote ideas of the national, and the donation of the cup occurred at a moment in history when Canadian nationalists needed identifying symbols. Jordan B. Goldstein asserts that only with a transformation in Anglo-liberal thought could the state legitimately act through culture to affect national identity. Drawing on primary source documentation from Lord Stanley's archives, as well as statements by politicians and hockey enthusiasts, Canada's Holy Grail integrates political thought into the realm of sport history through the discussion of a championship trophy that still stands as one of the most well-known and recognized Canadian national symbols.

The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. Recent progress in the science of clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies. The aim is to improve personalised medicine - not simply to prescribe the right medicine, but to deliver the right drug at the right dose at the right time. This textbook brings together contributions from leading experts to discuss the latest information on how human genetics impacts drug response phenotypes. It presents not only the basic principles of pharmacogenetics, but also clinically valuable examples that cover a broad range of specialties and therapeutic areas. The first section of the book outlines critical concepts in pharmacogenetics and pharmacogenomics, including genetic testing, genotyping technologies, and adverse drug effects. The next section discusses the legal, ethical, and social implications of pharmacogenomics. The second half of the book details many of the main therapeutic areas, including oncologic drugs, cardiovascular drugs, statins, drug-induced long QT syndrome, diabetes drugs, respiratory drugs, gastrointestinal drugs, rheumatoid arthritis drugs, obstetric drugs, psychiatric drugs, pain and anesthesia drugs, HIV and antiretroviral drugs, pediatrics, and fetal and neonatal medicine. This textbook is an invaluable introduction to pharmacogenetics and pharmacogenomics for health care professionals, medical students, pharmacy students, graduate students and researchers in the biosciences. RESOURCES @ www.cambridge.org/altman Link to the Pharmacogenomics Knowledgebase study guides images from the book discussion questions content updates.

In 1892, Lord Frederick Arthur Stanley donated the Dominion Hockey Challenge Cup - later known as the Stanley Cup - to crown the first Canadian hockey champions. Canada's Holy Grail documents Lord Stanley's personal politics, his desire to affect Canadian nationality and unity, and the larger transformations in Anglo-liberal political thought at the time. This book posits that the Stanley Cup fit directly within Anglo-American traditions of using sport to promote ideas of the national, and the donation of the cup occurred at a moment in history when Canadian nationalists needed identifying symbols. Jordan B. Goldstein asserts that only with a transformation in Anglo-liberal thought could the state legitimately act through culture to affect national identity. Drawing on primary source documentation from Lord Stanley's archives, as well as statements by politicians and hockey enthusiasts, Canada's Holy Grail integrates political thought into the realm of sport history through the discussion of a championship trophy that still stands as one of the most well-known and recognized Canadian national symbols.

David B. Goldstein argues for a new understanding of Renaissance England from the perspective of communal eating. Rather than focus on traditional models of interiority, choice and consumption, Goldstein demonstrates that eating offered a central paradigm for the ethics of community formation. The book examines how sharing food helps build, demarcate and destroy relationships - between eater and eaten, between self and other, and among different groups. Tracing these eating relations from 1547 to 1680 - through Shakespeare, Milton, religious writers and recipe book authors - Goldstein shows that to think about eating was to engage in complex reflections about the body's role in society. In the process, he radically rethinks the communal importance of the Protestant Eucharist. Combining historicist literary analysis with insights from social science and philosophy, the book's arguments reverberate well beyond the Renaissance. Ultimately, Eating and Ethics in Shakespeare's England forces us to rethink our own relationship to food.

An urgent plea for a broader understanding and awareness of the unconsidered dangers of new genetic technologies Since 2010 it has been possible to determine a person's genetic makeup in a matter of days at an accessible cost for many millions of people. Along with this technological breakthrough there has emerged a movement to use this information to help prospective parents "eliminate preventable genetic disease." As the prospect of systematically excluding the appearance of unwanted mutations in our children comes within reach, David B. Goldstein examines the possible consequences from these types of choices. Engaging and accessible, this clarion call for responsible and informed stewardship of the human genome provides an overview of what we do and do not know about human genetics and looks at some of the complex, yet largely unexplored, issues we must be most careful about as we move into an era of increasing numbers of parents exercising direct control over the genomes of their children.

Over the past three decades, the population of international students throughout the world has steadily increased. Although university students choose to study in locations other than their home country for a variety of reasons, including professional development and disciplinary training, nearly all education abroad programs have intercultural learning as a central goal. In this Element, perspectives derived from cross-cultural psychological research are applied to an investigation of the effectiveness of study abroad as a mechanism for intercultural learning. Effectiveness is broadly defined and includes not only overall favorable program outcomes, such as gains in intercultural skills, knowledge, attitudes, and awareness, but also a recognition that study abroad experiences and outcomes may vary depending upon participants' diverse and intersectional identities. Best practices for facilitating intercultural learning through study abroad are identified and strategies are outlined for addressing the methodological challenges of research in this area.

David B. Goldstein argues for a new understanding of Renaissance England from the perspective of communal eating. Rather than focus on traditional models of interiority, choice and consumption, Goldstein demonstrates that eating offered a central paradigm for the ethics of community formation. The book examines how sharing food helps build, demarcate and destroy relationships - between eater and eaten, between self and other, and among different groups. Tracing these eating relations from 1547 to 1680 - through Shakespeare, Milton, religious writers and recipe book authors - Goldstein shows that to think about eating was to engage in complex reflections about the body's role in society. In the process, he radically rethinks the communal importance of the Protestant Eucharist. Combining historicist literary analysis with insights from social science and philosophy, the book's arguments reverberate well beyond the Renaissance. Ultimately, Eating and Ethics in Shakespeare's England forces us to rethink our own relationship to food.

Evolution is a new book on evolutionary biology that integrates molecular biology, genomics, and human genetics with traditional studies of evolutionary processes. Recommended as a primary textbook for undergraduate courses in evolution Required reading for biologists seeking a clear, current, and comprehensive account of evolutionary theory and mechanisms Written by experts in population genetics, bacterial genomics, paleontology, human genetics, and developmental biology Integrates molecular and evolutionary biology in ways that reflect current directions in research Contents and Coverage This extensively illustrated, full-color book has four sections: Introduction (Part I) gives an account of how the ideas underpinning evolutionary theory developed and a history of experiments and ideas in the development of molecular biology. Origin and Diversification of Life (Part II) describes the history of life on earth from the origin of life to the evolution of humans, with emphasis on the major transitions in genetic organization and novel adaptations that have appeared. The diversity of life is emphasized. The chapters make extensive use of information from complete genome sequences and analysis of molecular mechanisms in development. Evolutionary Processes (Part III) describes how the diversity of life is generated: How variation arises and how selection acts are considered in detail. Many examples used to illustrate these processes are drawn from molecular sources. Human Evolution (Part IV) discusses human evolution and diversity. The benefits of molecular markers for our understanding of human evolution are highlighted and these findings integrated with paleontological evidence. Also discussed is the use of evolutionary methods to identify genetic differences that predispose people to specific diseases and affect their responses to treatment. Online-only Chapters Additional chapters, found on the Web only, deal with techniques and models used in studying evolutionary biology, emphasizing the contribution of molecular biology and genomics to phylogenetic reconstruction methods. Resources for Instructors The Evolution Web site (www.evolution-textbook.org) is an invaluable supplement to the textbook, a resource for teachers that will contain downloadable figures (for PowerPoint or overhead display) and chapter problems. Request exam copies and other information Visit the Evolution Web site now for more information about this new book. Request a detailed Table of Contents, Sample Chapters, Exam Copies, and Updates about Evolution.

The Global Positioning System (GPS) is now a global utility. The United States Air Force is the steward responsible for sustaining and modernizing the constellation. The current launch-to-sustain strategy implemented by the Air Force is not flexible, does not effectively support GPS modernization, and it does not lend itself to a future responsive launch paradigm.

Investing in the future of Hopewell archae- adetailedagendaofpressingempiricalissues ology is the spirit in which this book has andintriguinginterpretivequestionsthatremain beenwrittenandisitssubstance. Ourpassion to be addressed in the attempt to understand to do so derives from our admiration of Hopewellpeoples. Hopewell peoples, themselves, and all they The first half of the book provides a achieved. Hopewell peoples of the Scioto synthesisandexpansionofcurrentknowledge valley and their neighbors were remarkable about the anthropology of Scioto Hopewell by any measure. Their graceful and powerful peoples: their natural and symbolically int- artwork, monumentalearthenarchitecture, and preted environments, subsistence, settlement knowledge of geometry and astronomy; their andmobilitypatterns, communityorganization social finesse in choreographing ritual perfor- at several scales, social-political-ritual orga- manceswithmanyhundredsofpersons, local zation, and world view, and the history of and foreign; the long-lasting intercommunity changes of each of these over time. Coming peacetheyachievedthroughtherichandcross- to an understanding of how Scioto Hopewell cuttingsocialandritualtiestheywove;andtheir social-ceremonial life abruptly began and extraordinary sensitivity to and relations with abruptlyended, neitherofwhichweretriggered theanimalpersonsandspiritbeingswithwhom proximally by subsistence or demographic they cohabited-each humble the Western change, isoneofthefruitsbornfromattempting mind. Forus, itseemsonlyrightandworthwhile thebroadsynthesis. Theethnohistorypresented thatanempiricalandconceptualpathbecleared hereismadetangiblewithover195photographs wherebyfuturearchaeologicalworkmighthelp of artistic renderings that Scioto Hopewell Hopewellpeoplestospeakbetterforthemselves peoples made of themselves, of artifacts that oftheirlives, accomplishments, concerns, and marked their social roles and were used in disappointments. theirceremonies, andofviewsoftheirsacred This book shares with you the empirical landscape. toolsandabroadvisionforexploringtheways The reconstruction of Scioto Hopewell of Scioto Hopewell and other Ohio Hopewell life presented in this book is an integratio

A geneticist explains the science behind genetic history and what it has revealed about Jewish origins Who are the Jews? Where did they come from? What is the connection between an ancient Jewish priest in Jerusalem and today's Israeli sunbather on the beaches of Tel Aviv? These questions stand at the heart of this engaging book. Geneticist David Goldstein analyzes modern DNA studies of Jewish populations and examines the intersections of these scientific findings with the history (both biblical and modern) and oral tradition of the Jews. With a special gift for translating complex scientific concepts into language understandable to all, Goldstein delivers an accessible, personal, and fascinating book that tells the history of a group of people through the lens of genetics. In a series of detective-style stories, Goldstein explores the priestly lineage of Jewish males as manifested by Y chromosomes; the Jewish lineage claims of the Lemba, an obscure black South African tribe; the differences in maternal and paternal genetic heritage among Jewish populations; and much more. The author also grapples with the medical and ethical implications of our rapidly growing command of the human genomic landscape. The study of genetics has not only changed the study of Jewish history, Goldstein shows, it has altered notions of Jewish identity and even our understanding of what makes a people a people.

Eating and drinking-vital to all human beings-were of central importance to Shakespeare and his contemporaries. Culinary Shakespeare, the first collection devoted solely to the study of food and drink in Shakespeare's plays, reframes questions about cuisine, eating, and meals in early modern drama. As a result, Shakespearean scenes that have long been identified as important and influential by scholars can now be considered in terms of another revealing cultural marker-that of culinary dynamics. Renaissance scholars, as David Goldstein and Amy Tigner point out, have only begun to grapple with the importance of cuisine in literature. An earlier generation of criticism concerned itself principally with cataloguing the foodstuffs in the plays. Recent analyses have operated largely within debates about humoralism and dietary literature, consumption, and interiority, working to historicize food in relation to the early modern body. The essays in Culinary Shakespeare build upon that prior focus on individual bodily experience but also transcend it, emphasizing the aesthetic, communal, and philosophical aspects of food, while also presenting valuable theoretical background. As various essays demonstrate, many of the central issues in Shakespeare studies can be elucidated by turning our attention to the study of food and drink. The societal and religious associations of drink, for example, or the economic implications of ingredients gathered from other lands, have meaningful implications for our understanding of both early modern and contemporary periods-including aspects of community, politics, local and global food production, biopower and the state, addiction, performativity, posthumanism, and the relationship between art and food. Culinary Shakespeare seeks to open new interpretive possibilities and will be of interest to scholars and students of Shakespeare and the early modern period as well as to those in food studies, food history, ecology, gender and domesticity, and critical theory.