This volume is the proceedings of the 3rd IEEE International Conference on Knowledge Innovation and Invention 2020 (IEEE ICKII 2020). The conference was organized by the IEEE Tainan Section Sensors Council (IEEE TSSC), the International Institute of Knowledge Innovation and Invention (IIKII), and the National University of Kaohsiung, Taiwan, and held on August 21-23, 2020 in Kaohsiung.This volume of Knowledge Innovation on Design and Culture selected 95 excellent papers from the IEEE ICKII 2020 conference in the topics of Innovative Design and Cultural Research and Knowledge Innovation and Invention. This proceedings presents the research results based on the interdisciplinary collaboration of social sciences and engineering technologies by international networking in the academic and industrial fields.