Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.

Do you know that black holes can affect time? that Stonehenge is a giant calendar? that the Oracle Bones of the North China Plain predict the phases of the moon? that the Pyramids are giant compasses? how Jonathan Swift knew that Mars had two moons when he wrote Gulliver's Travels? that the effects of black holes are described in the story of Alice in Wonderland? that an atomic reactor existed 2 billion years ago in Equatorial Africa? that an electron on the other side of the galaxy can deflect a billiard ball? that Schr dingers cat is both alive and dead? Derek York fathoms these and many other mysteries of time and space in In Search of Lost Time. A reflection of York's obsession with time and its measurement, the book discusses the mind-bending universe of the special and general theories of relativity, the ghostly world of quantum mechanics, and the unpredictable haunts of chaos. It explores the pyramids of Egypt, Stonehenge, and the South China plain; the universities of Cambridge, McGill, and Chicago; the Patent Office in Berne; and back to the Ethiopian desert on the banks of the Awash River. Companions to share and illuminate the path range from Jonathan Swift's Gulliver's Travels and Lewis Carroll's Alice in Wonderland to J.B. Priestley's Dangerous Corner. It also presents the father of master-spy Kim Philby in the Empty Quarter of Arabia, the fantasist Velikovsky in the clouds, and Newton, Darwin, Rutherford, Einstein and the great Earth scientists of this century who fathomed the depths of lost time and discovered the age of the Earth. Written in an engaging, nontechnical style, this book will delight and amaze all who encounter it.

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Do you know
that black holes can affect time?
that Stonehenge is a giant calendar?
that the Oracle Bones of the North China Plain predict the phases of the moon?
that the Pyramids are giant compasses?
how Jonathan Swift knew that Mars had two moons when he wrote Gulliver's Travels?
that the effects of black holes are described in the story of Alice in Wonderland?
that an atomic reactor existed 2 billion years ago in Equatorial Africa?
that an electron on the other side of the galaxy can deflect a billiard ball?
that Schrodingers cat is both alive and dead?
Derek York fathoms these and many other mysteries of time and space in In Search of Lost Time. A reflection of York's obsession with time and its measurement, the book discusses the mind-bending universe of the special and general theories of relativity, the ghostly world of quantum mechanics, and the unpredictable haunts of chaos.
It explores the pyramids of Egypt, Stonehenge, and the South China plain; the universities of Cambridge, McGill, and Chicago; the Patent Office in Berne; and back to the Ethiopian desert on the banks of the Awash River. Companions to share and illuminate the path range from Jonathan Swift's Gulliver's Travels and Lewis Carroll's Alice in Wonderland to J.B. Priestley's Dangerous Corner. It also presents the father of master-spy Kim Philby in the Empty Quarter of Arabia, the fantasist Velikovsky in the clouds, and Newton, Darwin, Rutherford, Einstein and the great Earth scientists of this century who fathomed the depths of lost time and discovered the age of the Earth.
Written in an engaging, nontechnical style, this book will delight and amaze all who encounter it."

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

As in the widely popular earlier editions, the latest revision of this comprehensive and systematic text approaches the Bible from a literary/historical perspective, studying it as a body of writing produced by real people who intended to convey messages to actual audiences. Avoiding assessments of the Bible's truth or authority, the authors maintain a rigorously objective tone as they discuss such major issues as the forms and strategies of biblical writing, its actual historical and physical settings, the process of canon formation, and the nature of biblical genres including prophecy, apocalypse, and gospel.
The fifth edition features a new coauthor, David Citino; a new chapter by contributor Nicola Denzey on the essential yet often overlooked role of women in the Bible; and a new appendix on modern approaches to the Bible. It also incorporates new maps, a timeline, updated bibliographies, and revised material throughout. This objective, easy-to-use, and exciting presentation of the Bible is indispensable to students and accessible to general readers.

Lena James is tired of the timid life she used to live. She decides to go on a final senior trip with her high school to Guatemala to make the first step into her new life. On her first day in Guatemala she meets Adam, a twenty-something Aussie who is a restaurant owner in Antigua. As Lena starts to fall head-over-heels for Adam, his secret of being involved with the drug cartel turns her world upside down. Lena is taken after a drug deal gone bad. Love, drugs, guns, friends and savages fill the pages as Adam finds his way to rescue Lena. Will he make it in time?

A dark cloud follows Dr. Eric Stevens, a young and hardworking psychiatrist. Painful thoughts of his deceased wife have continually haunted him since tragic her death. Hiding his problems, he tries to assist his psychiatric patients with theirs.

After finding him leaning over the mutilated body of his fiancee, a rough edged detective brings in a new patient covered in blood. Everything around Eric becomes crazed and his patients become fearful.

Unbeknownst to Eric, something dark and evil has grown interested in him. Those around him fall victim and the only saving grace...is murder.