With contributions by Clarke, G.; Lang, R.E.; McKinley, M.J.; Merrick, L.P.; Rascher, W.; Richter, D.; Sofroniew, M.; Unger, T.; Weindl, A.

There is no doubt that a major problem of present day research workers, especially in the life sciences, is the plethora of publications of all kinds, abstracts, short communications, full papers in journals of varying quality, reviews and proceedings of symposia with, in addition, an unprecedented duplication of publications. Even for experts working in the field, it is almost impossible to keep an up-to-date view of all current research articles. The Western grant and career system encourages scientists to publish as much as possible. The editors and publishers of our new series are convinced that the format of Current Topics in Neuroendocrinology leads a way out of this confusion. Each volume is conceived as a concise up-to-date textbook on one well-defined and currently exciting subject. Different from classic textbooks, however, the speed of publication compares favorably with that of many journals; this ensures an immediacy which is im possible in textbooks. On the other hand, topics to be included in this series are also sufficiently reliable, with enough work being done to treat them from several aspects. Each volume will supply four to six chapfers treating such a broad topic as neuroendocrinology from several points of view, for example, anatomic, electrophysiologic, endocrine and behavioral views. Wh re clinical data are immediately available, they will be included. No other 36Iles treating the nervous or endocrine systems provides such a coordinated set of chapters on an interesting topic in each volume."

The most prominent function of the central nervous system is the control of motor functions by rapidly transmitted impulses through efferent cranial and spinal peripheral nerves. Besides electrically transmitted neural impulses, humoral mechanisms with more sustained actions are exercised by the brain and spinal cord to regulate body homeostasis. Thus, the brain may be regarded as an "endocrine gland" discharging neurohormones (peptides) either into the general circulation (neurohypophyseal hormones) or into the hypothalamo-adenohypophyseal portal circulation (releasing and inhibiting hormones). The brain, therefore, which is protected by the blood-brain barrier from disturbing and potentially noxious exogenous and endogenous agents circulating in the blood, has to have certain neurohemal regions beyond this barrier, such as the neural lobe and the median eminence (infundibulum), where neurohor mones have free access to the blood stream. To regulate somatic and autonomic functions in the best possible way, the central nervous system is highly dependent on feedback signals conveyed through somatic and visceral afferent nerves as well as on peripheral humoral signals such as peripheral hormones and other circulating substances that are under homeostatic regulation, e. g., peptides, arnines, electrolytes, and other biologically active agents. In this chapter, the role of the blood-brain barrier in the regulation of these sub stances will be discussed with special emphasis on the access through the blood-brain barrier to cardiovascular centers. 2 The Blood-Brain Barrier 2."

It is well established that progesterone plays a role in the brain and hypophysis as a facilitator and inhibitor of sexual behavior and gonadotropin release in the female rat (Everett 1961; Caligaris et al. 1971; Brown-Grant and Naftolin 1972; Dorner 1972; Meyerson 1972; Barraclough 1973; Goldman and Zarrow 1973; Mann and Barraclough 1973; Freeman et al. 1976; Feder and Marrone 1977; Goodman 1978; Attardi 1981), guinea pig (Morin and Feder 1974), and primates (Odell and Swerdloff 1968; Spies and Niswender 1972; Yamaji et al. 1972; Karsch et al. 1973; Dierschke et al. 1973; Knobi11974; Clifton et al. 1975). In an attempt to learn whether a specific progesterone uptake mechanism exists in the brain and the hypophysis, the distribution and retention pattern of radioactivity after in vivo injection of labeled progesterone was studied. Early work of Kato (1963) did not show a selective uptake of radioactivity in the hypo- thalamus of immature and estrogen-primed immature rats after injection oflow- specific-activity [14C]progesterone, but some tendency of the reticular formation to take up radiation was observed. Laumas and Farooq (1966) reported that after intravenous administration of labeled progesterone to ovariectomized estrogen- treated rats, radioactivity in the brain and pituitary appeared to show a very slight, insignificant increase 1-2 min after injection, but the uptake pattern was not definite, as had been seen with estradiol. Seiki et al.

Studienarbeit aus dem Jahr 2005 im Fachbereich Ingenieurwissenschaften - Wirtschaftsingenieurwesen, Note: 1,7, Hochschule Pforzheim, Veranstaltung: Logistik 6, 30 Quellen im Literaturverzeichnis, Sprache: Deutsch, Abstract: Unternehmen sind in der heutigen Zeit einem turbulenten Umfeld ausgesetzt. Der vollzogene Wandel vom Verkaufer- zum Kaufermarkt hat zur Folge, dass die Zahl der Produktvarianten stark zunimmt. Gleichzeitig unterliegen die Preise den Folgen eines Uberangebots. Der hohe Wettbewerbsdruck fuhrt dazu, dass die Marktreife (time-to-market) der Produkte immer schneller erreicht werden muss, um entsprechende Gewinne realisieren zu konnen. Weitere sich dynamisch andernde Rahmenbedingungen, wie beispielsweise die Globalisierung der Waren- und Informationsflusse, die rasanten Entwicklungen in der Logistik- und Kommunikationstechnik sowie der Einfluss von Standorten mit unterschiedlichen Markt- und Kostenstrukturen, fuhren zu einer Intensivierung des Wettbewerbs. Die anhaltende Entwicklung, Wertschopfungsbereiche in eigene Niederlassungen im Ausland oder an externe Partner abzugeben, erfordert einen deutlich hoheren Koordinationsaufwand fur die Projektorganisation und den Projektablauf, der mit dem klassischen Ansatz des Projektmanagement nicht beherrschbar ist. Um die Kundenanforderungen berucksichtigen zu konnen, mussen sowohl die Produkte, als auch die Organisation und die Prozesse des Unternehmens dynamisch an die individuellen Bedurfnisse der Kunden angepasst werden. Daruber hinaus sind alle am Wertschopfungsprozess beteiligten Unternehmen in diesen laufenden Veranderungsprozess zu integrieren. Eine sich dynamisch diesen Veranderungsprozessen anpassende Unternehmens- bzw. Prozessorganisation ist damit entscheidend, Geschaftsprozesse effizient und effektiv steuern zu konnen. Ferner sind moderne Informations- und Wissensmanagementsysteme notwendig, um global verteilte Wertschopfungsprozesse abwickeln und unterstutzen zu konnen. Nur wem es gelingt, die w