This book explores the remarkable information correspondences and probability structures of proteins. Correspondences are pervasive in biochemistry and bioinformatics: proteins share homologies, folding patterns, and mechanisms. Probability structures are just as paramount: folded state graphics reflect Angstrom-scale maps of electron density. The author explores protein sequences (primary structures), both individually and in sets (systems) with the help of probability and information tools. This perspective will enhance the reader's knowledge of how an important class of molecules is designed and put to task in natural systems, and how we can approach class members in hands-on ways.

This book explores the remarkable information correspondences and probability structures of proteins. Correspondences are pervasive in biochemistry and bioinformatics: proteins share homologies, folding patterns, and mechanisms. Probability structures are just as paramount: folded state graphics reflect Angstrom-scale maps of electron density. The author explores protein sequences (primary structures), both individually and in sets (systems) with the help of probability and information tools. This perspective will enhance the reader's knowledge of how an important class of molecules is designed and put to task in natural systems, and how we can approach class members in hands-on ways.

Whether we realize it or not, we think of our brains as computers. In neuroscience, the metaphor of the brain as a computer has defined the field for much of the modern era. But as neuroscientists increasingly reevaluate their assumptions about how brains work, we need a new metaphor to help us ask better questions. The computational neuroscientist Daniel Graham offers an innovative paradigm for understanding the brain. He argues that the brain is not like a single computer-it is a communication system, like the internet. Both are networks whose power comes from their flexibility and reliability. The brain and the internet both must route signals throughout their systems, requiring protocols to direct messages from just about any point to any other. But we do not yet understand how the brain manages the dynamic flow of information across its entire network. The internet metaphor can help neuroscience unravel the brain's routing mechanisms by focusing attention on shared design principles and communication strategies that emerge from parallel challenges. Highlighting similarities between brain connectivity and the architecture of the internet can open new avenues of research and help unlock the brain's deepest secrets. An Internet in Your Head presents a clear-eyed and engaging tour of brain science as it stands today and where the new paradigm might take it next. It offers anyone with an interest in brains a transformative new way to conceptualize what goes on inside our heads.

Whether we realize it or not, we think of our brains as computers. In neuroscience, the metaphor of the brain as a computer has defined the field for much of the modern era. But as neuroscientists increasingly reevaluate their assumptions about how brains work, we need a new metaphor to help us ask better questions. The computational neuroscientist Daniel Graham offers an innovative paradigm for understanding the brain. He argues that the brain is not like a single computer-it is a communication system, like the internet. Both are networks whose power comes from their flexibility and reliability. The brain and the internet both must route signals throughout their systems, requiring protocols to direct messages from just about any point to any other. But we do not yet understand how the brain manages the dynamic flow of information across its entire network. The internet metaphor can help neuroscience unravel the brain's routing mechanisms by focusing attention on shared design principles and communication strategies that emerge from parallel challenges. Highlighting similarities between brain connectivity and the architecture of the internet can open new avenues of research and help unlock the brain's deepest secrets. An Internet in Your Head presents a clear-eyed and engaging tour of brain science as it stands today and where the new paradigm might take it next. It offers anyone with an interest in brains a transformative new way to conceptualize what goes on inside our heads.

A simple, ten-step system for mastering the art of effective, persuasive business or technical writing

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In the sixth and fifth centuries B.C. a new kind of thinker appeared in Greek city-states, dedicated to finding the origins of the world and everything in it, using observation and reason rather than tradition and myth. We call these thinkers Presocratic philosophers, and recognize them as the first philosophers of the Western tradition, as well as the originators of scientific thinking. New textual discoveries and new approaches make a reconsideration of the Presocratics at the beginning of the twenty-first century especially timely.
This handbook brings together leading international scholars to study the diverse figures, movements, and approaches that constitute Presocratic philosophy. More than a survey of scholarship, this study presents new interpretations and evaluations of the Presocratics' accomplishments, from Thales to the sophists, from theology to science, and from pre-philosophical background to their influence on later thinkers. Many positions presented here challenge accepted wisdom and offer alternative accounts of Presocratic theories.
This handbook includes chapters on the Milesians (Thales, Anaximander, Anaximenes), Xenophanes, Heraclitus, Parmenides, Anaxagoras, Empedocles, the Pythagoreans, the atomists, and the sophists. Special studies are devoted to the sources of Presocratic philosophy, oriental influences, Hippocratic medicine, cosmology, explanation, epistemology, theology, and the reception of Presocratic thought in Aristotle and other ancient authors.

Publication of the "New South African Review, " produced from the department of sociology at the University of the Witwatersrand, " "represents the launch of an exciting new annual series of studies in South African politics, economics, and society. Drawing together original contributions, Volume 1 2010 will range widely over South Africa's location in the global economic crisis, the mounting environmental challenges facing the country, and the extent of poverty and unemployment through to the state of Zuma's ANC, land reform, and other critical issues confronting South African society: crime, child trafficking, HIV-Aids, indigent management, the justice system, and so on. Controversial, challenging and critical, the collection is framed by the question of whether South Africa can shift from a present path heralding long-term decline to a more optimistic future of global competitiveness and sustainable development. A vital read for all those wishing to keep track of present policies, trends, and outcomes in South African political economy. Contributors to the volume include: Devan Pillay, Mark Swilling, Mike Muller on the environmental crisis; Neva Magketla, Seeraj Mohammed, Sam Kariuki, Doreen Atkinson, and Scarlett Cornellison on the economy; Anthony Butler, Maxi Schoeman, Liezl Loots and Kammila Naidoo on politics; Colin Hoag, Prishani Naidoo, Jeremy Gordin and Louis Reynolds on state policy; Zosa de Sas Kropiwnicki, Hein Marais, Peter Vale, Loren Landau, Tara Polzer, Aurelia Wa Kabwe Segatti, Terry Ann Selikow, and Graham Gibbon on society and crisis; Roger Southall on development or decline.

This introduction to hacking covers everything you need to know to start your own journey to becoming an ethical hacker. With help from a lab setup that lets you hack along to each chapter, this book walks you through a variety of the most useful activities for any hacker. You'll begin by capturing and viewing a victim's traffic, then learn how to encrypt files and fake emails, and craft sophisticated social engineering attacks. In the later chapters, you'll learn how to fuzz, write trojans and rootkits, and perform website exploitation. Along the way, you'll develop a fundamental understanding of technologies like network protocols, websites, and the Linux operating system. You'll also work with tools used by professional penetration testers, such as Metasploit and Wireshark, and go from setting up a virtual lab environment for small scale hacks that could take place in a coffee shop to expanding this skill in order to take over an extensive corporate network. This manual is a must f

In Science before Socrates, Daniel Graham argues against the prevalent belief that the Presocratic philosophers did not produce any empirical science and that the first major Greek science, astronomy, did not develop until at least the time of Plato. Instead, Graham proposes that the advances made by Presocratic philosophers in the study of astronomy deserve to be considered as scientific contributions. Whereas philosophers of the sixth century BC treated astronomical phenomena as ephemeral events continuous with weather processes, those of the fifth century treated heavenly bodies as independent stony masses whirled in a cosmic vortex. Two historic events help to date and account for the change: a solar eclipse in 478 BC and a meteoroid that fell to earth around 466. Both events influenced Anaxagoras, who transformed insights from Parmenides into explanations of lunar and solar eclipses, meteors, and rainbows. Virtually all philosophers came to accept Anaxagoras' theory of lunar light and eclipses. Aristotle endorsed Anaxagoras' theory of eclipses as a paradigm of scientific explanation. Anaxagoras' theories launched a geometrical approach to astronomy and were accepted as foundational principles by all mathematical astronomers from Aristarchus to Ptolemy to Copernicus and Galileo-and to the present day.

In the sixth and fifth centuries B.C. a new kind of thinker appeared in Greek city-states, dedicated to finding the origins of the world and everything in it, using observation and reason rather than tradition and myth. We call these thinkers Presocratic philosophers, and recognize them as the first philosophers of the Western tradition, as well as the originators of scientific thinking. New textual discoveries and new approaches make a reconsideration of the Presocratics at the beginning of the twenty-first century especially timely.
This handbook brings together leading international scholars to study the diverse figures, movements, and approaches that constitute Presocratic philosophy. More than a survey of scholarship, this study presents new interpretations and evaluations of the Presocratics' accomplishments, from Thales to the sophists, from theology to science, and from pre-philosophical background to their influence on later thinkers. Many positions presented here challenge accepted wisdom and offer alternative accounts of Presocratic theories.
This handbook includes chapters on the Milesians (Thales, Anaximander, Anaximenes), Xenophanes, Heraclitus, Parmenides, Anaxagoras, Empedocles, the Pythagoreans, the atomists, and the sophists. Special studies are devoted to the sources of Presocratic philosophy, oriental influences, Hippocratic medicine, cosmology, explanation, epistemology, theology, and the reception of Presocratic thought in Aristotle and other ancient authors.

Be honest. Are you normal? Are your friends and family normal? If the answer to either question is "No," this book will make you feel better about yourself. Either it will make you feel normal by comparison, or it will help you understood what makes a person become, remain, and grow ever increasingly not-normal.

For example, you learn that "not-normal" is...

...genetic. You inherit it from your not-normal ancestors, like the one who drills holes in the floor to fix a leaky roof. You pass the not-normal gene to your children, like the two who play Peter Pan and Captain Hook with real cutlery.

...self-selective, like the high school friends with a roast pig bomb, or an Army staff sergeant with a strong attachment to his wife's prosthetic leg, or the business partner flaunting deelie-boppers at interviews.

...attitude, a wild mixture of payback and chain yanking.

If you find that you are not-normal, I have three more questions for you. Are we related? Do I know you? Are you in this book?

This work of fiction satirizes a church scandal that took place in Manassas, Virginia between 1998 and 2002. The chronology and many details come directly from court depositions and newsprint articles, and many of the quotations come directly from church-sponsored lecturers and publications. The story unfolds with a predator priest using his role as a spiritual director to seduce a woman in his flock. The local bishop engages in a sordid cover-up. A good priest is persecuted for helping the aggrieved husband. Welcome to the Hotel Novus Ordo suggests a different outcome than the real-life story. Irony and humor highlight the underlying causes of the scandal and lessen the pain of reliving the events.

On the planet Klamdara, several members of the elite fighting force of the Alliance known as the Tenebrea -- including their leader, Hal K'Rin -- are imprisoned, dying, and hoping for rescue. On the planet Cor, that hope resides in Andrea Flores, one of the Tenebrea's best operatives, and her ragtag group of wilderness clones. But Andrea has never lost sight of her true reason for joining the Tenebrea: to take revenge upon the murderers of her husband and daughter.
However, the rescue of K'Rin leads Andrea to an awful truth that he is hiding about Andrea's past, one that will throw her quest for revenge into chaos
Andrea Flores's long, difficult road to avenge the deaths of her loved ones comes to a head in the shocking conclusion to the Tenebrea trilogy

One piercing energy beam is enough to shatter the calm of a seaport on a sunny day. Just one shot turns an idle dreamer into a hardened avenger. Enraged by the brutal terrorist attack that kills her entire family, Andrea Flores leaves behind a world she loves. Abandoning Earth forever to even the score, Andrea finds herself an outcast on the harsh planet Jod, where she fights to join an elite unit, the powerful and mysterious Tenebrea. With the universe on the brink of destruction, Andrea must survive against all odds until the day she can face her family's killers and taste the revenge for which she lives.

Andrea Flores has become one of the most valued agents of the Tenebrea, the elite fighting force of the star-spanning Alliance. Following the destruction of the Clone Welfare Institute run by the Cor Ordinate, Andrea is sent on a vital mission alongside her comrades, H'Roo Parh, a Jod; Tara Gullwing, a clone -- and Tara's lover, Eric, the clone of Andrea's dead husband.
But Andrea has not forgotten her true reason for joining the Tenebrea: to take revenge on those responsible for the death of her husband and children -- Cor terrorists who mistook her husband for Eric. Now alongside a constant reminder of what she has lost, Andrea faces her greatest challenge yet...