Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science.

There have been few studies of the Law Lords, and no study of them by a political scientist for more than ten years. This book concentrates on the arguments the Law Lords use in justifying their decisions, and is concerned as much with the legal methodology as with the substance of their decisions. Very close attention is paid to the different approaches and styles of judicial argument, but the book is not restricted to this traditional analytic approach. One chapter applies the statistical techniques Americans call 'jurimetrics' and have successfully used on the US Supreme Court. The main theme is that the Law Lords enjoy and fully utilise far more discretion in their judgements than is normally admitted, and that much depends on exactly which judges happen to hear a case. the second part of the book shows the impact this extreme discretion has had in shaping both public law and areas of civil law.

"Brick by Brick" takes you inside the LEGO you've never seen. By following the teams that are inventing some of the world's best-loved toys, it spotlights the company's disciplined approach to harnessing creativity and recounts one of the most remarkable business transformations in recent memory.
"Brick by Brick" reveals how LEGO failed to keep pace with the revolutionary changes in kids' lives and began sliding into irrelevance. When the company's leaders implemented some of the business world's most widely espoused prescriptions for boosting innovation, they ironically pushed the iconic toymaker to the brink of bankruptcy. The company's near-collapse shows that what works in theory can fail spectacularly in the brutally competitive global economy.
It took a new LEGO management team - faced with the growing rage for electronic toys, few barriers to entry, and ultra-demanding consumers (ten-year old boys) - to reinvent the innovation rule book and transform LEGO into one of the world's most profitable, fastest-growing companies.
Along the way, "Brick by Brick" reveals how LEGO:
- Became truly customer-driven by co-creating with kids as well as its passionate adult fans
- Looked beyond products and learned to leverage a full-spectrum approach to innovation
- Opened its innovation process by using both the "wisdom of crowds" and the expertise of elite cliques
- Discovered uncontested, "blue ocean" markets, even as it thrived in brutally competitive red oceans
- Gave its world-class design teams enough space to create and direction to deliver
built a culture where "profitable" innovation flourishes
Sometimes radical yet always applicable, "Brick by Brick" abounds with real-world lessons for unleashing breakthrough innovation in your organization, just like LEGO. Whether you're a senior executive looking to make your company grow, an entrepreneur building a startup from scratch, or a fan who wants to instill some of that LEGO magic in your career, you'll learn how to build your own innovation advantage, brick by brick.

During the late Hellenistic and early Imperial periods (B.C. 50 - A.D. 300), important developments may be traced in the philosophy of language and its relationship to mind. This book examines theories of language in the work of theologians and philosophers linked to Ancient Alexandria. The growth of Judaism and Christianity in cultural centers of the Roman Empire, above all Alexandria, provides valuable testimony to the philosophical vitality of this period. The study of Later Greek philosophy should be more closely integrated with the Church Fathers, particularly in the theologically sensitive issue of the nature of language. Robertson traces some related attempts to reconcile immaterial, intelligible reality and the intelligibility of language, explain the structure of language, and clarify the nature of meaning. These shared problems are handled with greater philosophical sophistication by Plotinus, although the comparison with Philo, Clement, and Origen illustrates significant similarities as well as differences between Neoplatonism and early Jewish and Christian philosophy.

Providing explanations of the terminology, issues, organizations, and laws, this thoroughly revised and updated reference work reflects the growing international concern over human rights. Including over 200 clear and concise alphabetically arranged entries, A Dictionary of Human Rights is an essential resource for anyone concerned with human rights. Key Features: * Entries explaining terms connected with human rights such as Asylum, Equal Opportunities, Freedom of Speech, Representation, and Civil Liberties * Entries on organizations concerned with human rights such as Amnesty International, The European Court of Human Rights, and The American Civil Liberties Union * Outlines the significance of eminent thinkers such as Locke, Cardozo, and Nozick * Places key terms in their legal and constitutional context, with examples and explanations of their implications * Legal terms such as Injunction, Probable Cause, Clear and Present Danger, and Stop and Search are explained clearly and succinctly * An appendix containing texts and extracts of leading documents, such as The Declaration of the Rights of Man and the Citizen and The Universal Declaration of Human Rights.

This dictionary is the essential guide to politics, its terminologies, ideologies and institutions. Providing authoritative and up-to-date information that is invaluable to both students and general readers, it includes: well over 500 extensive definitions an understanding of the basics of political thought and theory clear, no-nonsense coverage of complex ideologies and dogmas succinct definitions of highly specialized and technical terms. Previously published by Penguin, this third edition has been extensively revised and updated with many new entries.

The logical and enduring way to innovate. Conventional wisdom today says that to survive, companies must move beyond incremental, sustaining innovation and invest in some form of radical innovation. "Disrupt yourself or be disrupted!" is the relentless message company leaders hear. The Power of Little Ideas argues there's a "third way" that is neither sustaining nor disruptive. This low-risk, high-reward strategy is an approach to innovation that all company leaders should understand so that they recognize it when their competitors practice it, and apply it when it will give them a competitive advantage. This distinctive approach has three key elements: It consists of creating a family of complementary innovations around a product or service, all of which work together to make that product more appealing and competitive. The complementary innovations work together as a system to carry out a single strategy or purpose. Crucially, unlike disruptive or radical innovation, innovating around a key product does not change the central product in any fundamental way. In this powerful, practical book, Wharton professor David Robertson illustrates how many well-known companies, including CarMax, GoPro, LEGO, Gatorade, Disney, USAA, Novo Nordisk, and many others, used this approach to stave off competitive threats and achieve great success. He outlines the organizational practices that unintentionally torpedo this approach to innovation in many companies and shows how organizations can overcome those challenges. Aimed at leaders seeking strategies for sustained innovation, and at the quickly growing numbers of managers involved with creating new products, The Power of Little Ideas provides a logical, organic, and enduring third way to innovate.

In a remarkable feat of historical detective work, David Robertson illuminates the shadowy figure who planned a slave rebellion so daring that, if successful, it might have changed the face of the antebellum South. This is the story of a man who, like Nat Turner, Marcus Garvey, and Malcolm X, is a complex yet seminal hero in the history of African American emancipation.

Denmark Vesey was a charasmatic ex-slave--literate, professional, and relatively well-off--who had purchased his own freedom with the winnings from a lottery. Inspired by the success of the revolutionary black republic in Haiti, he persuaded some nine thousand slaves to join him in a revolt. On a June evening in 1822, having gathered guns, and daggers, they were to converge on Charleston, South Carolina, take the city's arsenal, murder the populace, burn the city, and escape by ship to Haiti or Africa. When the uprising was betrayed, Vesey and seventy-seven of his followers were executed, the matter hushed by Charleston's elite for fear of further rebellion. Compelling, informative, and often disturbing, this book is essential to a fuller understanding of the struggle against slavery.

This volume provides a comprehensive assessment of the likely effects of the Uruguay Round agreements on the dynamic economies of East Asia. The rapid development of these countries owes much to the strong export performance and unilateral deregulation of their economies in recent years. Their major stake in maintaining the integrity of the global trading system was demonstrated by their active participation in the negotiations. The impact of the Uruguay Round liberalisation on East Asian economic development and policies is evaluated using sophisticated CGE models to estimate the effects on trade and income. The strengthening of trade rules and dispute settlement procedures are examined by a group of world trade experts. They establish that some gaps in the system remain to be tackled (anti-dumping, regional discrimination) and that some new problems are pending (competition policy, investment).

Although the authors believe that the level of conventional and nuclear forces in Europe should and will be reduced, they do not consider that the military instrument will have lost all of its value in European political affairs. They still see a need to be prepared for tension and conflict.

The Quiet Man Roars is the enthralling story of David Robertson, one of the finest attacking full-backs Scotland has produced in the last 30 years. Spotted as a schoolboy, Robertson signed as an apprentice with Aberdeen in the early 1980s. Initially a winger, a series of unfortunate events saw David selected at left-back for a youth game and he never looked back. He made his debut for Aberdeen at 17 and was snapped up by Rangers for just shy of GBP1m at age 22. David was an integral part of the Rangers side that won nine successive league championships and came within an ace of reaching the first Champions League final. Later, he played in the English Premiership for Leeds United before injury cut short his playing career, prompting a move into management. As a player, he was the epitome of the modern day marauding full-back. As a coach, he has already made his mark across the globe and been the subject of a BAFTA-winning BBC documentary. The Quiet Man Roars is the inside story of one of football's most respected characters.

The relevance of this book to central concerns of political and social science hardly needs emphasizing. Parties are the organizing force of democratic governments, giving coherence and direction to their policies and relating them to popular preferences. Election programmes are crucial to this role, providing electors with some insight into the policies they are voting for, and parties themselves with a starting point for their activity in government. Discussion begins with a comparative assessment of the impact of election pledges on government action. The book goes on to describe systematically the place of the programmes in the political process of nineteen democracies. It subjects them to detailed qualitative, quantitative and spatial analyses to answer such questions as: Who prepares election programmes and how? What is the nature of modern party divisions? Do they differ across countries? Is there indeed an 'end of ideology' or an intensification? Does the need to attract votes weaken old partisan attachments? Combining individual studies of each country with comparative analyses on a scale never previously undertaken, the book will interest country specialists and comparativists and prove indispensable to research on voting and party behaviour, coalition formation, ideology, and rational choice.

After decades of extraordinary successes as a multicultural society, new debates are bubbling to the surface in Canada. The contributors to this volume examine the conflict between equality rights, as embedded in the Charter, and multiculturalism as policy and practice, and ask which charter value should trump which and under what circumstances? The opening essay deliberately sharpens the conflict among religion, culture, and equality rights and proposes to shift some of the existing boundaries. Other contributors disagree strongly, arguing that this position might seek to limit freedoms in the name of justice, that the problem is badly framed, or that silence is a virtue in rebalancing norms. The contributors not only debate the analytic arguments but infuse their discussion with their personal experiences, which have shaped their perspectives on multiculturalism in Canada. This volume is a highly personal as well as strongly analytic discussion of multiculturalism in Canada today.

Series Information:
Routledge Dictionaries

The relevance of this book to central concerns of political and social science hardly needs emphasizing. Parties are the organizing force of democratic governments, giving coherence and direction to their policies and relating them to popular preferences. Election programmes are crucial to this role, providing electors with some insight into the policies they are voting for, and parties themselves with a starting point for their activity in government. Discussion begins with a comparative assessment of the impact of election pledges on government action. The book goes on to describe systematically the place of the programmes in the political process of nineteen democracies. It subjects them to detailed qualitative, quantitative and spatial analyses to answer such questions as: Who prepares election programmes and how? What is the nature of modern party divisions? Do they differ across countries? Is there indeed an 'end of ideology' or an intensification? Does the need to attract votes weaken old partisan attachments? Combining individual studies of each country with comparative analyses on a scale never previously undertaken, the book will interest country specialists and comparativists and prove indispensable to research on voting and party behaviour, coalition formation, ideology, and rational choice.