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Transcription, or the process by which DNA produces RNA, is a
central aspect of gene expression. Transcription factors regulate
transcription during development and in disease states. As such, it
is critical for researchers to gain a good understanding of the
relationship between the structure of various families of
transcription factors and their function, as well as roles in human
disease. Since publication of the Fourth Edition, there have been
major advances, notably in the areas of chromatin remodeling and
genome-scale analyses. This complete update includes all new
coverage of the latest developments, from enabling genomic
technologies to studies on the importance of post-translational
modifications beyond phosphorylation events.
Brand new coverage in this edition includes:
* Potential of transcription factors as therapeutic targets in
human disease
* Importance of histone modifications
* Use of genome-based sequence analysis and high-throughput methods
* Applications of the chromatin immunoprecipitation (ChIP) assay
* Transcriptional elongation
* Regulation by post-translational modifications
* Regulatory networks and bioinformatics
This work is concerned with a group of proteins which were
originally consid ered to be an esoteric phenomenon but which have
now been shown to play critical roles both in normal and stressed
cells as well as being involved in a variety of human diseases. It
is the purpose of this work to give a comprehen sive view of these
proteins and their various aspects. After an introductory chapter
providing an overview of these proteins, the work is divided into
four main sections each of which deals with one important aspect of
these proteins. Thus, the first section contains a series of
chapters which describe individual stress proteins and their roles
in particular biological phenomena. Evidently, the induction of
these proteins by elevated tempera ture or other stresses is their
defining feature and the second section of this book therefore
considers the regulation of stress protein gene expression both by
stressful stimuli such as elevated temperature or ischaemia and by
non stressful stimuli such as cytokines.
This work is concerned with a group of proteins which were
originally consid ered to be an esoteric phenomenon but which have
now been shown to play critical roles both in normal and stressed
cells as well as being involved in a variety of human diseases. It
is the purpose of this work to give a comprehen sive view of these
proteins and their various aspects. After an introductory chapter
providing an overview of these proteins, the work is divided into
four main sections each of which deals with one important aspect of
these proteins. Thus, the first section contains a series of
chapters which describe individual stress proteins and their roles
in particular biological phenomena. Evidently, the induction of
these proteins by elevated tempera ture or other stresses is their
defining feature and the second section of this book therefore
considers the regulation of stress protein gene expression both by
stressful stimuli such as elevated temperature or ischaemia and by
non stressful stimuli such as cytokines.
Gene therapy offers considerable potential for the treatment of
various incurable diseases of the nervous system. This volume
describes a number of different viral vectors developed for
achieving high efficiency gene delivery to the brain. Vectors
described include those based on adenovirus, adeno-associated
virus, Herpes Simplex Virus, lentivirus, and other retroviruses. It
also discusses the potential application of such viruses in
treating brain tumors, Parkinson's disease, and other diseases of
the nervous system.
* Provides up-to-date account of gene therapy approaches for
incurable neurological disorders
* Describes a range of gene delivery methods based on different
viruses
Neuroscience Perspectives provides multidisciplinary reviews of
topics in one of the most diverse and rapidly advancing fields in
the life sciences.
Whether you are a new recruit to neuroscience, or an established
expert, look to this series for 'one-stop' sources of the
historical, physiological, pharmacological, biochemical, molecular
biological and therapeutic aspects of chosen research areas.
The recent development of Gene Therapy procedures which allow
specific genes to be delivered to human patients who lack
functional copies of them is of major therapeutic importance. In
addition such gene delivery methods can be used in other organisms
to define the function of particular genes. These studies are of
particular interest in the nervous system where there are many
incurable diseases like Alzheimer's and Parkinson's diseases which
may benefit from therapies of this kind. Unfortunately gene
delivery methods for use in the nervous system have lagged behind
those in other systems due to the fact that the methods developed
in other systems are often not applicable to cells like neurons
which do not divide. This book discusses a wide range of methods
which have now been developed to overcome these problems and allow
safe and efficient delivery of particular genes to the brain.
Methods discussed include virological methods, physical methods
(such as liposomes) and the transplantation of genetically modified
cells. In a single volume therefore this book provides a complete
view of these methods and indicates how they can be applied to the
development of therapies for treating previously incurable
neurological disorders.
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