This volume brings together world-leading scholars on the thought of Averroes, the greatest medieval commentator on Aristotle but also a major scholar of Islam. The collection situates him in his historical context by emphasizing the way that he responded to the political situation of twelfth-century Islamic Spain and the provocations of Islamic theology. It also sheds light on the interconnections between aspects of his work that are usually studied separately, such as his treatises on logic and his legal writings. Advanced students and scholars will find authoritative and insightful treatments of Averroes' philosophy, tackled from multiple perspectives and written in a clear and accessible way that will appeal to those encountering his work for the first time as well as to anyone looking for new critical approaches to Averroes and his thinking.

This book provides information and tools necessary to bridge and integrate the knowledge gaps related to the acquisition and processing of archaeological data, specifically in the field of preventive diagnostics, urban centers, archaeological parks and historical monuments, through activities that involve the application of non-invasive diagnostic detection systems, in the field of applied geophysics. The principal aim of this book is to define a tool for experts that work in the frame of Cultural Heritage and to identify a procedure of intervention transferable and usable in different geographical contexts and areas of investigations: it could help to decide the better technique of investigation to apply in relation to the predictive characteristics of the archaeological site and the objectives of the survey. The book is divided in two parts. The first one explains the theory of ground high resolution penetrating radar (GPR), electrical resistivity tomography (ERT), controlled source electromagnetism system, differential magnetic method and the scenario of integrated methods of different geophysical techniques. Each section covers the basic theory (complete description of the physical parameters involved in the method), field instruments (description of all systems actually offered by commercial companies), field techniques (presentation of the main procedures and setting parameters used to explore the ground surface during data acquisition), techniques of data processing and representation (main processing routines and comparison between different techniques; presentation of different typologies of graphical representation), and the possibility and limitations of methods (explanation of best and worst conditions of implementation of the geophysical technique in relation to the contrasts between archaeological features and the natural background and the features of the instruments and arrays). The second part describes some applications of geophysical prospection to Cultural Heritage in detailed case histories, divided in sections relative to monuments, historical buildings, urban centres, archaeological parks and ancient viability. Moreover, examples of integration of three-dimensional reliefs and geophysical diagnostic of a monuments and studies of large scale reconnaissance implemented into a Geographical Information System are treated. In each case study the authors cover the description of the archaeological or historical contest; an explanation of the problem to solve; a choice of the geophysical methods; the setting of the procedure of data acquisition; techniques of data processing; a representation, interpretation, and discussion of the results.

5-HT2A receptors are G-protein coupled receptors that are widely distributed throughout the brain, most notably on neuronal and glial cells. 5-HT2A receptors have been implicated in various central physiological functions including mood regulation, memory, sleep, nociception, eating, and reward behaviors, and they are also believed to control the cardiovascular system. This book provides a comprehensive overview of these receptors including sections on their properties and distribution, approaches for their study, their role in a number of brain functions and diseases, and their role as therapeutic targets.

G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.

Metabotropic glutamate receptors (mGluRs) are members of the group C family of G-protein-coupled receptors. Eight different mGlu subtypes have been identified and classified into three groups based on amino acid sequence similarity, agonist pharmacology, and the signal transduction pathways to which they couple. They perform a variety of functions in the central and peripheral nervous systems, being involved in learning, memory, anxiety, and the perception of pain. They are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and cerebral cortex, as well as other parts of the bain and peripheral tissues. This volume will focus on the latest research in the role of Group I mGluRs in health and disease.

A masterpiece of war reportage, The Morning They Came for Us bears witness to one of the most brutal internecine conflicts in recent history. Drawing from years of experience covering Syria for Vanity Fair, Newsweek, and the front page of the New York Times, award-winning journalist Janine di Giovanni chronicles a nation on the brink of disintegration, all written through the perspective of ordinary people. With a new epilogue, what emerges is an unflinching picture of the horrific consequences of armed conflict, one that charts an apocalyptic but at times tender story of life in a jihadist war zone. The result is an unforgettable testament to resilience in the face of nihilistic human debasement.

Since its first application, microdialysis has become incredibly popular to study brain function and has been applied with success in different fields from psychopharmacology, neurobiology, and physiology in animals and also humans. "Microdialysis Techniques in Neuroscience" focuses on the practical aspects of microdialysis in animal and human, highlighting current technical limitations and providing a vision of what is yet to come for the determination of the most disparate compounds in the brain. The book s contents range from new techniques for detection and quantifying the release of several different neurotransmitters in vitro and in vivo, even in freely moving animals, to sophisticated use of reverse dialysis and the application of microdialysis in pharmacokinetic studies. Each of the sixteen chapters, in fitting with the spirit of the "Neuromethods" series, contain an introduction that gives a broad overview of a focused topic, followed by an extensive protocol on how the experiments are performed along with invaluable practical advice.

Detailed and authoritative, "Microdialysis Techniques in Neuroscience" will be a valuable reference for students, neuroscientists, and physicians for the use of microdialysis in the study of brain functions and its clinical applications."

Research of 5-HT2c receptors stretches back twenty-five years, and while much of it has been productive, the past decade of research has been extraordinary in terms of both amount produced and insights gained. It is hardly surprising that 5-HT2c receptor research has grown so fruitful, given that it is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a major role in the regulation of numerous behaviors. It has further been shown by experimental and clinical observation that it may represent a possible therapeutic target for the development of drugs for a range of central nervous system disorders. The time, therefore, is more than appropriate to offer the first ever overview of the research of 5-HT2c receptors. Part of the popular and important series, "The Receptors," The 5-HT2c Receptor provides a thorough update of the functional status of the 5-HT2c receptor. It covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor so as to highlight its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. In addition, the book investigates the receptors' therapeutic potential in a range of different diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson's disease, Prader-Willi Syndrome, Alzheimer's disease and epilepsy. While not exhaustive, this text is a vital tool in understanding the past and inspiring the future of interdisciplinary research on the 5-HT2c receptor.

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed "tonic" inhibition, has been described. Whereas synaptic GABAA receptors underlie classical "phasic" GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

Karl Leonhard Reinhold (1757-1823) is a complex figure of the late German Enlightenment. Sometime Catholic priest and active Mason even when still a cleric in Vienna; early disciple of Kant and the first to try to reform the Critique of Reason; influential teacher and prolific author; astute commentator on the immediate post-Kantian scene; and at all times convinced propagandist of the Enlightenment--in all these roles Reinhold reflected his age but also tested the limits of the values that had inspired it. This collection of essays, originally presented at an international workshop held in Montreal in 2007, conveys this multifaceted figure of Reinhold in all its details. In the four themes that run across the contributions--the historicity of reason; the primacy of moral praxis; the personalism of religious belief; and the transformation of classical metaphysics into phenomenology of mind--Reinhold is presented as a catalyst of nineteenth century thought but also as one who remained bound to intellectual prejudices that were typical of the Enlightenment and, for this reason, as still the representative of a past age. The volume contains the text of two hitherto unpublished Masonic speeches by Reinhold, and a description of recently recovered transcripts of student lecture notes dating to Reinhold's early Jena period.

Flat and Corrugated Diaphragm Design Handbook provides simple, useful methods for diaphragmdesign, performance evaluation, and material selection. The text is a practical andcomplete guide to solving on-the-job problems faced by instrument designers; structural engineersdesigning plates, panels, and floors; and mechanical engineers designing flexural pivots,couplings, and elastic elements.A leading design engineer has written this authoritative reference for the benefit of his colleaguesin the engineering community. Each chapter is user-oriented and features clear, stepby-step techniques which are easily translated into improved diaphragm design. The text includesa simple algebraic presentation of performance characteristics, and computer results ofspecific shapes, profiles, and corrugation depths. Special topics, such as the use of diaphragmsas pressure summing devices and the design of semiconductor diaphragms for solid state transducers,receive outstanding coverage in this book. Each discussion contains many detailed examplesand illustrations.Flat and Corrugated Diaphragm Design Handbook is a vital addition to both the workbenchand the library of every practicing design engineer. This volume is also an excelJent textbookfor a course on instrument design and application for senior-level engineering students.

Hegel and the Challenge of Spinoza explores the powerful continuing influence of Spinoza's metaphysical thinking in late eighteenth- and early nineteenth-century German philosophy. George di Giovanni examines the ways in which Hegel's own metaphysics sought to meet the challenges posed by Spinoza's monism, not by disproving monism, but by rendering it moot. In this, di Giovanni argues, Hegel was much closer in spirit to Kant and Fichte than to Schelling. This book will be of interest to students and researchers interested in post-Kantian Idealism, Romanticism, and metaphysics.

Hegel and the Challenge of Spinoza explores the powerful continuing influence of Spinoza's metaphysical thinking in late eighteenth- and early nineteenth-century German philosophy. George di Giovanni examines the ways in which Hegel's own metaphysics sought to meet the challenges posed by Spinoza's monism, not by disproving monism, but by rendering it moot. In this, di Giovanni argues, Hegel was much closer in spirit to Kant and Fichte than to Schelling. This book will be of interest to students and researchers interested in post-Kantian Idealism, Romanticism, and metaphysics.

'Moments in Hell' reveals the conflicting loyalties of the war correspondent, caught between political ideologies and personal suffering, and provides enlightening background to recent conflicts.

This volume explores the expansion of audiovisual translation studies and practices within European institutions, universities and businesses. The wide variety of contributions from researchers and practitioners from different countries and backgrounds reflects the rapid pace and complex nature of this expansion. The first section is dedicated to the multiple relations and intersections of AVT with culture and demonstrates how translation is conditioned by the (in)correct perception and codification of cultural values, both in dubbing and subtitling. The second section focuses on new perspectives on media accessibility, providing a comprehensive overview of the latest developments in this relatively young but growing area. The contributions are in line with a new trend in the field of AVT that presents accessibility as both an asset and a universal right, thus highlighting the importance of increased accessibility to audiovisual media content for all viewers.

**Longlisted Moore Prize for Human Rights Writing** 'A tragic portrait of a disappearing world, created with passion and literary grace' SALMAN RUSHDIE 'Janine di Giovanni is a humane and persistent witness' HISHAM MATAR 'Profoundly moving' MARK TULLY _______________________ The Vanishing reveals the plight and possible extinction of Christian communities across Syria, Egypt, Iraq, Lebanon and Palestine after 2,000 years in their historical homeland. Some of the countries that first nurtured and characterized Christianity - along the North African Coast, on the Euphrates and across the Middle East and Arabia - are the ones in which it is likely to first go extinct. Christians are already vanishing. We are past the tipping point, now tilted toward the end of Christianity in its historical homeland. Christians have fled the lands where their prophets wandered, where Jesus Christ preached, where the great Doctors and hierarchs of the early church established the doctrinal norms that would last millennia. From Syria to Egypt, the cities of northern Iraq to the Gaza Strip, ancient communities, the birthplaces of prophets and saints, are losing any living connection to the religion that once was such a characteristic feature of their social and cultural lives. In The Vanishing, Janine di Giovanni has combined astonishing journalistic work to discover the last traces of small, hardy communities where ancient rituals are quietly preserved amid 360 degree threats. Full of faith and hope, di Giovanni's riveting personal stories make a unique act of pre-archeology: the last chance to visit the living religion before all that will be left are the stones of the past.